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Overview

Uniprot IDA0A287B3S3
Protein NameInter-alpha-trypsin inhibitor heavy chain H1
Gene NameITIH1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
49 RSLKVNCKVTSRFAH

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MGLQGLLCLC 20 LASHLALQAM 30 PTQGSPTDST 40 KGNKAVNGVV 50 IRSLKVNCKV 60 TSRFAHYVVT 70 SQVVNNANKA 80 KEVAFDVEIP 90 KTAFISDFAI 100 TADENTFVGD 110 IKDKVTAWKQ 120 YRKAAISGEN 130 SGLVRASGRT 140 MEQFTIHVTI 150 GPRSKATFQL 160 TYEEVLRRKL 170 TQYDIVIKVK 180 PKQLVQHFEI 190 DVDIFEPQGI 200 SKLDAQASFL 210 SKEAAAQLIK 220 KSFSGKKGHV 230 LFRPTVGQQQ 240 SCSTCSTTLL 250 NGDFKVTYDV 260 NREKLCDLLV 270 ANNYFAHFFA 280 PQNLTKLNKN 290 VVFVIDISSS 300 MEGQKVKQTK 310 EALLKILSDL 320 KPGDYFDLVL 330 FGSAVQSWRG 340 SLVQASTANL 350 DAARSYVRQF 360 SLAGSTNLNG 370 GLLRGIEILN 380 KAQGSLPEFS 390 NRASILIMLT 400 DGEPTEGVTD 410 RSQILKNVRD 420 AIRGRFPLYN 430 LGFGHDVDWN 440 FLEVMALENN 450 GRAQRIYEDH 460 DAAQQLQGFY 470 DQVANPLLKD 480 VELQYPADAV 490 LALTQHRHKQ 500 YYEGSEITVA 510 GRIADNKLSS 520 FKADVQASGD 530 QGFKTTCLVD 540 EEEMKKLLQE 550 RGHMLENYVE 560 RLWAYLTIQE 570 LLAKRMKLEG 580 AEKASVSAKA 590 LQMSLDYQFV 600 TPLTSMTIRG 610 MADKDGLEPV 620 IDKPLEGMEM 630 LGPRRKFVLS 640 ASQPSPTHPS 650 SSIQKLPDRV 660 TGVDTDPHFI 670 IRVPQKEDTL 680 CFNINEEPGV 690 VLSLVQDPDT 700 GFSVNGQLIG 710 NEARSPGKHE 720 GTYFGRLGIA 730 NPATGFQLEV 740 TPQNITLNPG 750 SGGPVFSWRD 760 QASLRQDEVV 770 VTINRKRNLV 780 VSVEDGGTFE 790 VVLHRVWKGS 800 AIHQDFLGFY 810 VLDSHRMSAR 820 THGLLGQFFH 830 PFDYKVSDLH 840 PGSDPTKTDA 850 TMVVKNRQLT 860 VTRGLQKDYS 870 KDPRHGAKVT 880 CWFIHNNGDG 890 LIDGVHTDYI VPDIF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0005540 hyaluronic acid binding
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0030212 hyaluronan metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.