Search Results
Overview
| Uniprot ID | A0A287B4B7 |
|---|---|
| Protein Name | Rab GDP dissociation inhibitor |
| Gene Name | GDI2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | TEGSFVYKGGKIYKV |
| 164 | TFEGVDPKKTAMREV |
| 210 | CETINRIKLYSESLA |
| 269 | NGKVIGVKSEGEIAR |
| 278 | EGEIARCKQLICDPS |
| 288 | ICDPSYVKDRVEKVG |
| 293 | YVKDRVEKVGQVIRV |
| 360 | ASTTVETKEPEKEIR |
| 418 | ETTCDDIKDIYKRIG |
Function
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A
Protein Sequence
10
MNEEYDVIVL
20
GTGLTECILS
30
GIMSVNGKKV
40
LHMDRNPYYG
50
GESASITPLE
60
DLYKRFNIPG
70
APPASMGRGR
80
DWNVDLIPKF
90
LMANGQLVKM
100
LLFTEVTRYL
110
DFKVTEGSFV
120
YKGGKIYKVP
130
STEAEALASS
140
LMGLFEKRRF
150
RKFLVYVANF
160
DENDPRTFEG
170
VDPKKTAMRE
180
VYKKFDLGQD
190
VIDFTGHALA
200
LYRTDDYLDQ
210
PCCETINRIK
220
LYSESLARYG
230
KSPYLYPLYG
240
LGELPQGFAR
250
LSAIYGGTYM
260
LNKPIEEIIV
270
QNGKVIGVKS
280
EGEIARCKQL
290
ICDPSYVKDR
300
VEKVGQVIRV
310
ICILSHPIKN
320
TSDANSCQII
330
IPQNQVNRKS
340
DIYVCMISSA
350
HNVAAQGKYI
360
AIASTTVETK
370
EPEKEIRPAL
380
ELLEPIEQKF
390
VSISDLLVPK
400
DLGTDSQIFI
410
SRTYDATTHF
420
ETTCDDIKDI
430
YKRIGGFPHP
440
IHVTNTGLFF
LVKDQF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.