Search Results

Overview

Uniprot IDA0A287B4N0
Protein NameGeneral transcription factor II-I
Gene NameGTF2I
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
130 CYGKALGKSTVVPVP
199 GGSCGPIKVKTEPTE
306 SPPTKRPKSNEPPQP
333 VREFNFEKWNARITD
358 RKYAQAIKAKGPVTI
406 LERILLAKERIRFVI
415 RIRFVIKKHELLNST
436 DKPASGVKEEWYARI
457 VDQLFCKKFAEALGS
506 YGIPRLEKIIQVGNR
553 VRITKLRKQVEEIFN
644 MASKINTKALQSPKR
803 KESTSSSKSPPRKIN

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSTLP 20 VEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKSTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVVV 160 QGLPEGVAFK 170 HPENYDLATL 180 KWILENKAGI 190 SFIIKRSMLS 200 PGGSCGPIKV 210 KTEPTEDSGI 220 SLEMAAVTVK 230 EESEDPDYYQ 240 YNIQAGPSET 250 DDVDDKLPLS 260 KSLQGSHHSS 270 EGNEGTEMEV 280 PAEDSTQHVP 290 SETSEDPEVE 300 VTIEDDDYSP 310 PTKRPKSNEP 320 PQPPVTEPAN 330 AGKRKVREFN 340 FEKWNARITD 350 LRKQVEELFE 360 RKYAQAIKAK 370 GPVTIPYPLF 380 QSHVEDLYVE 390 GLPEGIPFRR 400 PSTYGIPRLE 410 RILLAKERIR 420 FVIKKHELLN 430 STREDLQLDK 440 PASGVKEEWY 450 ARITKLRKMV 460 DQLFCKKFAE 470 ALGSTEAKAV 480 PYQKFEAHPN 490 DLYVEGLPEN 500 IPFRSPSWYG 510 IPRLEKIIQV 520 GNRIKFVIKR 530 PELLTHSTTE 540 VTQPRTNTPV 550 KEDWNVRITK 560 LRKQVEEIFN 570 LKFAQALGLT 580 EAVKVPYPVF 590 ESNPEFLYVE 600 GLPEGIPFRS 610 PTWFGIPRLE 620 RIVRGSNKIK 630 FVVKKPELVI 640 SYLPPGMASK 650 INTKALQSPK 660 RPRSPGSNSK 670 VPEIEVTVEG 680 PNNSNPQTSA 690 VRTPTQTNGS 700 NVPFKPRGRE 710 FSFEAWNAKI 720 TDLKQKVENL 730 FNEKCGEALG 740 LKQAVKVPFA 750 LFESFPEDFY 760 VEGLPEGVPF 770 RRPSTFGIPR 780 LEKILRNKAK 790 IKFIIKKPEM 800 FETAIKESTS 810 SSKSPPRKIN 820 SSPNVNTTAS 830 GVEDLNIIQV 840 TIPDDDNERL 850 SKVEKARQLR 860 EQVNDLFSRK 870 FGEAIGMGFP 880 VKVPYRKITI 890 NPGCVVVDGM 900 PPGVSFKAPS 910 YLEISSMRRI 920 LDSAEFIKFT 930 VIRPFPGLVI 940 NNREYFLKVF 950 HLFLFWGLKR 960 VCVCVFPCAH 970 TRGYLTYSIN HSQLLS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.