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Overview

Uniprot IDA0A287B555
Protein NameAnkyrin repeat and FYVE domain-containing protein 1
Gene NameANKFY1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1093 IIKFDLNKPVRVCNI

Function

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI[3]P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. Required for podocyte migration

Protein Sequence

10 MCVILPVLID 20 LKIKVGGRHI 30 NAHKFVLAAR 40 SDSWSLASLS 50 STEELDLSDA 60 NPEVTMTMLR 70 WIYTDELEFR 80 EDDVFLTELM 90 KLANRFQLQL 100 LRERCEKGVM 110 SLVNVRNCIR 120 FYQTAEELNA 130 STLVNYCAEI 140 IASHWDDLRK 150 EDFSSMGAQL 160 LYKMIKSKTE 170 YPLHKAIKVE 180 REDVVFLYLI 190 EMDSQLPGKL 200 NELDQNGDLA 210 LDLALSRRLE 220 SIASTLVSHK 230 ADVDMVDKNG 240 WSLLHKGIQR 250 GDLFAATFLI 260 KNGALVNAAT 270 LGAQETPLHL 280 VASYSSEKHS 290 AGVMSEMAQI 300 AEALLQAGAN 310 PNMQDSKGRT 320 PLHLSIMARN 330 EHVFNQLLQC 340 KQLDLELKDH 350 EGSTALWLAV 360 QYITVSSDQS 370 VNPFEDLPVV 380 NGTSFDENSF 390 AARLIQRGSN 400 TNAPDTVTGN 410 CLLQRAAEAG 420 NEAAALFLAT 430 SGAHVNHRNK 440 WGETPLHTAC 450 RHGLANLTAE 460 LLQQGANPNL 470 QTEEALPSPK 480 EAASLSGSAD 490 SSVSQQTPLH 500 MAIAYNHPDV 510 VSIILEQKAN 520 ALHATNNLQI 530 IPDFSLKDSR 540 DQTVLGLALW 550 TGMHTIAAQL 560 LGSGACINDT 570 MSDGQTLLHM 580 AMQRQDSKSA 590 LFLLEHQADI 600 NIRTQDGETA 610 LQLAIRNQLP 620 LVVDAICTRG 630 ADMSVPDEKG 640 NPPLWLALAN 650 NLEDIASTLV 660 RHGCDATCWG 670 PGPSGCLQTL 680 LHRAIDENNE 690 AIACFLIRSG 700 CDVNSPRQPG 710 ANGEGEEEAR 720 DGQTPLHLAA 730 SWGLEETIQC 740 LLEFGANVNA 750 QDAEGRTPVH 760 VAISNQHGVI 770 IQLLISHPDI 780 HLNVRDRQGL 790 TPFACAMTYK 800 NNKAAEAILK 810 RESGAAEQVD 820 NKGRNFLHVA 830 VQSSDIESVL 840 FLISVQANVN 850 SRVQDASKLT 860 PLHLAVQAGS 870 EIIVRNLLLA 880 GAKVNELTKH 890 RQTALHLAAQ 900 QDLPTICSVL 910 LENGVDFAAV 920 DENGNNALHL 930 AVMHGRLSNI 940 RVLLTECTVD 950 AEAFNLRGQS 960 PLHILGQYGK 970 ENAAAVFELF 980 LECMPEYPLD 990 KPDADGNTVL 1000 LLAYMKGNAN 1010 LCRAIVRSGA 1020 RLGVTNNQGV 1030 NIFNYQVATK 1040 QLLFRLLDML 1050 SKEPPWCDGS 1060 NCYECTAKFG 1070 VTTRKHHCRH 1080 CGRLLCHKCS 1090 TKEIPIIKFD 1100 LNKPVRVCNI 1110 CFDVLTLGGV S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0010008 endosome membrane
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006897 endocytosis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.