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Overview

Uniprot IDA0A287B5A2
Protein NameSodium/potassium-transporting ATPase subunit beta
Gene NameATP1B3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
137 DGKFLEQKGPHYDAC
182 MNRIIGLKPQGEPRI

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known

Protein Sequence

10 MTKKEKKSFN 20 QSMAEWKLFL 30 YNPTTGEFLG 40 RSAKSWGLIL 50 LFYLVFYVFL 60 AALFAFTMWV 70 MLQTLNDEVP 80 KYRDQISSPG 90 LMVFPKPVSA 100 LDYSFSVSDP 110 DSYKGYIDDL 120 KKFLKPYDLE 130 EQKNLTDCTD 140 GKFLEQKGPH 150 YDACRFPLNL 160 LEACSGEIDP 170 QFGYSRGNPC 180 ILVKMNRIIG 190 LKPQGEPRIE 200 CISKGESTAV 210 LSTYPPNGKI 220 DIKYFPYYGK 230 KLHGNYLQPL 240 VAVQLTFDAG 250 NDMNEVTVEC 260 KIDGSPNLKN 270 QDDRDKFLGR VAFKVTVHA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005890 sodium:potassium-exchanging ATPase complex
Molecular Function GO:0001671 ATPase activator activity
Biological Process GO:0030007 intracellular potassium ion homeostasis
Biological Process GO:0006883 intracellular sodium ion homeostasis
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0036376 sodium ion export across plasma membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.