Search Results

Overview

Uniprot IDA0A287B5D6
Protein NameAnkyrin repeat and FYVE domain-containing protein 1
Gene NameANKFY1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1164 IIKFDLNKPVRVCNI

Function

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI[3]P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. Required for podocyte migration

Protein Sequence

10 LTELQQDLRV 20 LCFLAEEVAK 30 LEKHLMLLRQ 40 EYVKLQKKLA 50 ETEKRCTLLA 60 AQANKESSSE 70 SFISRLLTIV 80 ADLYEQEQYS 90 DLKIKVGGRH 100 INAHKFVLAA 110 RSDSWSLASL 120 SSTEELDLSD 130 ANPEVTMTML 140 RWIYTDELEF 150 REDDVFLTEL 160 MKLANRFQLQ 170 LLRERCEKGV 180 MSLVNVRNCI 190 RFYQTAEELN 200 ASTLVNYCAE 210 IIASHWDDLR 220 KEDFSSMGAQ 230 LLYKMIKSKT 240 EYPLHKAIKV 250 EREDVVFLYL 260 IEMDSQLPGK 270 LNELDQNGDL 280 ALDLALSRRL 290 ESIASTLVSH 300 KADVDMVDKN 310 GWSLLHKGIQ 320 RGDLFAATFL 330 IKNGALVNAA 340 TLGAQETPLH 350 LVASYSSEKH 360 SAGVMSEMAQ 370 IAEALLQAGA 380 NPNMQDSKGR 390 TPLHLSIMAR 400 NEHVFNQLLQ 410 CKQLDLELKD 420 HEGSTALWLA 430 VQYITVSSDQ 440 SVNPFEDLPV 450 VNGTSFDENS 460 FAARLIQRGS 470 NTNAPDTVTG 480 NCLLQRAAEA 490 GNEAAALFLA 500 TSGAHVNHRN 510 KWGETPLHTA 520 CRHGLANLTA 530 ELLQQGANPN 540 LQTEEALPSP 550 KEAASLSGSA 560 DSSVSQQTPL 570 HMAIAYNHPD 580 VVSIILEQKA 590 NALHATNNLQ 600 IIPDFSLKDS 610 RDQTVLGLAL 620 WTGMHTIAAQ 630 LLGSGACIND 640 TMSDGQTLLH 650 MAMQRQDSKS 660 ALFLLEHQAD 670 INIRTQDGET 680 ALQLAIRNQL 690 PLVVDAICTR 700 GADMSVPDEK 710 GNPPLWLALA 720 NNLEDIASTL 730 VRHGCDATCW 740 GPGPSGCLQT 750 LLHRAIDENN 760 EAIACFLIRS 770 GCDVNSPRQP 780 GANGEGEEEA 790 RDGQTPLHLA 800 ASWGLEETIQ 810 CLLEFGANVN 820 AQDAEGRTPV 830 HVAISNQHGV 840 IIQLLISHPD 850 IHLNVRDRQG 860 LTPFACAMTY 870 KNNKAAEAIL 880 KRESGAAEQV 890 DNKGRNFLHV 900 AVQSSDIESV 910 LFLISVQANV 920 NSRVQDASKL 930 TPLHLAVQAG 940 SEIIVRNLLL 950 AGAKVNELTK 960 HRQTALHLAA 970 QQDLPTICSV 980 LLENGVDFAA 990 VDENGNNALH 1000 LAVMHGRLSN 1010 IRVLLTECTV 1020 DAEAFNLRGQ 1030 SPLHILGQYG 1040 KENAAAVFEL 1050 FLECMPEYPL 1060 DKPDADGNTV 1070 LLLAYMKGNA 1080 NLCRAIVRSG 1090 ARLGVTNNQG 1100 VNIFNYQVAT 1110 KQLLFRLLDM 1120 LSKEPPWCDG 1130 SNCYECTAKF 1140 GVTTRKHHCR 1150 HCGRLLCHKC 1160 STKEIPIIKF 1170 DLNKPVRVCN 1180 ICFDVLTLGG VS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0044354 macropinosome
Cellular Component GO:0030904 retromer complex
Molecular Function GO:1901981 phosphatidylinositol phosphate binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0034058 endosomal vesicle fusion
Biological Process GO:0090160 Golgi to lysosome transport
Biological Process GO:0048549 positive regulation of pinocytosis
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.