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Overview

Uniprot IDA0A287B5K1
Protein NamePolypyrimidine tract-binding protein 1
Gene NamePTBP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
147 YIQFSNHKELKTDSS
150 FSNHKELKTDSSPNQ
272 TLRIDFSKLTSLNVK
279 KLTSLNVKYNNDKSR
407 YGDVQRVKILFNKKE
449 PVRITLSKHQNVQLP
467 QEDQGLTKDYGNSPL
524 GGIVKGFKFFQKDRK

Function

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform

Protein Sequence

10 MGAGQLATRA 20 TPGVPSIVPD 30 IAVGTKRGSD 40 ELFSACVTNG 50 PFIMSSNSAS 60 TANGNDSKKF 70 KGDNRSAGVP 80 SRVIHIRKLP 90 SDVTEGEVIS 100 LGLPFGKVTN 110 LLMLKGKNQA 120 FIEMNTEEAA 130 NTMVNYYTSV 140 TPVLRGQPIY 150 IQFSNHKELK 160 TDSSPNQARA 170 QAALQAVNSV 180 QSGNLALAAS 190 AAAVDAGMAM 200 AGQSPVLRII 210 VENLFYPVTL 220 DVLHQIFSKF 230 GTVLKIITFT 240 KNNQFQALLQ 250 YADPVSAQHA 260 KLSLDGQNIY 270 NACCTLRIDF 280 SKLTSLNVKY 290 NNDKSRDYTR 300 PDLPSGDNQP 310 SLDQTMAAAF 320 GAPGIMSASP 330 YAGAGFPPTF 340 AIPQAAGLSV 350 PNVHGALAPL 360 AIPSAAAAAA 370 AAGRIAIPGL 380 AGAGNSVLLV 390 SNLNPERVTP 400 QSLFILFGVY 410 GDVQRVKILF 420 NKKENALVQM 430 ADGSQAQLAM 440 SHLNGHKLHG 450 KPVRITLSKH 460 QNVQLPREGQ 470 EDQGLTKDYG 480 NSPLHRFKKP 490 GSKNFQNIFP 500 PSATLHLSNI 510 PPSISEEDLK 520 ILFSSNGGIV 530 KGFKFFQKDR 540 KMALIQMGSV 550 EEAIQALIDL 560 HNHDLGENHH 570 LRVSFSKSTI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1903312 negative regulation of mRNA metabolic process
Biological Process GO:0008380 RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.