Search Results
Overview
| Uniprot ID | A0A287B5Q3 |
|---|---|
| Protein Name | Threonine--tRNA ligase, mitochondrial |
| Gene Name | TARS2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 222 | KLRLIDEKITGPKAT |
Function
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain
Protein Sequence
10
MGLYRRWRRL
20
RLPGLQACGL
30
HTAAVPTPPH
40
WLVERLGFFE
50
ELWTAQVKKL
60
ASMAQKEHRA
70
IKVSLPGGRK
80
VDAVAWNTTP
90
YQLAQQISSK
100
LADTAVAAVV
110
NGEPYDLERP
120
LEKDSDLRFL
130
TFDSAEGKAV
140
FWHSSTHVLG
150
AAAEQFLGAV
160
LCQGPSTECG
170
FYHDFFLGKE
180
RTVRGSELPV
190
LEQICQELAA
200
AAQPFRRLEA
210
SRDQLRQLFK
220
DNPFKLRLID
230
EKITGPKATV
240
YGCGMLVDLC
250
RGPHLRHTGQ
260
IGGLKLLTAE
270
YTRRGFLEVK
280
TPTLFSTKLW
290
ELSGHWEHYR
300
EDMFALQPSG
310
TDGPASSQSD
320
HSTSHPTDTL
330
ALKPMNCPAH
340
CLMFAHRPRS
350
WRELPLRLAD
360
FGALHRAEAS
370
GSLGGLTRLR
380
CFQQDDAHIF
390
CAPDQLEAEI
400
RGCLDFLRSV
410
YTVLGFSFRL
420
ALSTRPSGFL
430
GEPCLWDQAE
440
QVLQQALEEF
450
GEPWDLNPGD
460
GAFYGPKIDV
470
HVRDALGRPH
480
QCGTIQLDFQ
490
LPLRFDLQYK
500
GQAEALERPV
510
LIHRAVLGSV
520
ERMLGVLAES
530
CGGKWPLWLS
540
PFQVVVIPVG
550
SEQEEYAREA
560
QQSLRAAGLV
570
GDLDADSGLT
580
LSRRVRRAQL
590
AHYNFQFVVG
600
QKEQSKRTVN
610
IRTRDNHRLG
620
ERDLAEAVQR
630
LLELQNTRVP
NAEEIF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004829 | threonine-tRNA ligase activity |
| Biological Process | GO:0006435 | threonyl-tRNA aminoacylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.