Search Results
Overview
| Uniprot ID | A0A287B5Q7 |
|---|---|
| Protein Name | 26S proteasome non-ATPase regulatory subunit 8 |
| Gene Name | PSMD8 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | RKSPNLSKCGEELGR |
| 139 | TTGTKLTKQQLILAR |
| 278 | EIAGCIEKAYEKILF |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair
Protein Sequence
10
MFVKGRPSRA
20
PPRKRLSTKR
30
GVRRPTVAAP
40
PPALGSTYRA
50
HFRRASGSRR
60
RCRKSARRFA
70
ASRKMAAATV
80
NGVAGGSSSG
90
PAAASGAVLQ
100
AAAGMYEQLK
110
GEWNRKSPNL
120
SKCGEELGRL
130
KLVLLELNFL
140
PTTGTKLTKQ
150
QLILARDILE
160
IGAQWSILRK
170
DIPSFERYMA
180
QLKCYYFDYK
190
EQLPESAYMH
200
QLLGLNLLFL
210
LSQNRVAEFH
220
TELERLPAKD
230
IQTNVYIKHP
240
VSLEQYLMEG
250
SYNKVFLAKG
260
NIPAESYTFF
270
IDILLDTIRD
280
EIAGCIEKAY
290
EKILFTEATR
300
ILFFNTPKKM
310
TDYAKKRGWV
320
LGLNNYYSFA
330
SQQQKPEDTT
340
IPSTELAKQV
350
IEYARQLEMI
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0008541 | proteasome regulatory particle, lid subcomplex |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.