Search Results
Overview
| Uniprot ID | A0A287B6A4 |
|---|---|
| Protein Name | Inosine-5'-monophosphate dehydrogenase |
| Gene Name | IMPDH2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 243 | RDYPLASKDAKKQLL |
| 247 | LASKDAKKQLLCGAA |
| 443 | FSEADKIKVAQGVSG |
| 455 | VSGAVQDKGSIHKFV |
| 516 | HSLHSYEKRLF**** |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MADYLISGGT
20
SYVPDDGLTA
30
QQLFNCGDGL
40
TYNDFLILPG
50
YIDFTADQVD
60
LTSALTKKIT
70
LKTPLVSSPM
80
DTVTEAGMAI
90
AMAVSIVVLA
100
SFTTTWGGKE
110
PETLCLKATE
120
EDQKYEQGFI
130
TDPVVLSPKD
140
RVRDVFEAKA
150
QHGFCGIPIT
160
DTGRMGSRLV
170
GIISSRDIDF
180
LKEEEHDRFL
190
EEIMTKREDL
200
VVAPAGITLK
210
EANEILQRSK
220
KGKLPIVNED
230
DELVAIIART
240
DLKKNRDYPL
250
ASKDAKKQLL
260
CGAAIGTHED
270
DKYRLDLLAQ
280
AGVDVVVLDS
290
SQGNSIFQIN
300
MIKYIKEKYP
310
SLQVIGGNVV
320
TAAQAKNLID
330
AGVDALRVGM
340
GSGSICITQE
350
VLACGRPQAT
360
AVYKVSEYAR
370
RFGVPVIADG
380
GIQNVGHIAK
390
ALALGASTVM
400
MGSLLAATTE
410
APGEYFFSDG
420
IRLKKYRGMG
430
SLDAMDKHLS
440
SQNRYFSEAD
450
KIKVAQGVSG
460
AVQDKGSIHK
470
FVPYLIAGIQ
480
HSCQDIGAKS
490
LTQVRAMMYS
500
GELKFEKRTS
510
SAQVEGGVHS
LHSYEKRLF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006177 | GMP biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.