Search Results
Overview
| Uniprot ID | A0A287B6W1 |
|---|---|
| Protein Name | Transforming growth factor beta-1-induced transcript 1 protein |
| Gene Name | TGFB1I1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 211 | GLCGSCNKPIAGQVV |
| 498 | FCLRPLTKGSFQERA |
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways
Protein Sequence
10
MPRSGALKER
20
PPEPLTSPLP
30
QMGSGESSGA
40
SGDKDHLYST
50
VCKPRSPKPA
60
APAAPPFSSS
70
CGVLGTGLCE
80
LDRLLQELNA
90
TQFNITDEIM
100
SQFPSSKESA
110
GEKKEDPSED
120
KKRPSPPPSP
130
TPVLPKPSAT
140
SATLELDRLM
150
ASLSDFRVQN
160
HLPASGPTQP
170
AVPSSVNEGS
180
PSPPGPTSQG
190
SLDTMLGLLQ
200
SDLSRRGVPT
210
QAKGLCGSCN
220
KPIAGQVVTA
230
LGRAWHPEHF
240
VCGGCSTALG
250
GSSFFEKDGA
260
PFCPECYFER
270
FSPRCGLCNQ
280
PIRHKMVTAL
290
GTHWHPEHFC
300
CVSCGEPFGD
310
EGFHEREGRP
320
YCRRDFLQLF
330
APRCQGCQGP
340
ILDNYISALS
350
ALWHPDCFVC
360
RVRGCGGAAW
370
GGRAHGGRDY
380
GPGGGATIPS
390
TQPAETRLRL
400
CGRLGRGRPG
410
CEGLPGYSAR
420
KASYLVWSLA
430
LIHPFAAAFP
440
QECFAPFSGG
450
SFFEHEGRPL
460
CENHFHARRG
470
SLCATCGLPV
480
TGRCVSALGR
490
RFHPDHFTCT
500
FCLRPLTKGS
510
FQERAGKPYC
QPCFLKLFG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016363 | nuclear matrix |
| Molecular Function | GO:0070411 | I-SMAD binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0050681 | nuclear androgen receptor binding |
| Molecular Function | GO:0048495 | Roundabout binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0043542 | endothelial cell migration |
| Biological Process | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| Biological Process | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0034446 | substrate adhesion-dependent cell spreading |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.