Search Results
Overview
| Uniprot ID | A0A287B7A0 |
|---|---|
| Protein Name | tRNA-splicing ligase complex subunit RTRAF |
| Gene Name | RTRAF |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 188 | LTQDAVAKANQTKEG |
| 193 | VAKANQTKEGLPVAL |
| 20 | NPAGFNCKDETEFRN |
| 41 | DQKIRHYKIEDRGNL |
| 5 | ***MFRRKLTALDYH |
| 62 | DWPKFFEKYLRDVNC |
| 72 | RDVNCPFKIQDRQEA |
Function
Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Could also play a role in RNA transport
Protein Sequence
10
MFRRKLTALD
20
YHNPAGFNCK
30
DETEFRNFIV
40
WLEDQKIRHY
50
KIEDRGNLRN
60
IHSSDWPKFF
70
EKYLRDVNCP
80
FKIQDRQEAI
90
DWLLGLAVRL
100
EYGDNANHIS
110
TTAKDGILGT
120
KFTEKYKDLV
130
PDNTKNADNA
140
AKNAEPLINL
150
DVNNPDFKAG
160
VMALANLLQI
170
QRHDDYLVML
180
KAIRILVQER
190
LTQDAVAKAN
200
QTKEGLPVAL
210
DKHILGFDTG
220
DAVLNEAAQI
230
LRLLHIEELR
240
ELQTKINEAI
250
VAVQAIIADP
260
KTDHRLGKVG
R
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0072669 | tRNA-splicing ligase complex |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000993 | RNA polymerase II complex binding |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.