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Overview

Uniprot ID	A0A287B7N8
Protein Name	ATP-dependent 6-phosphofructokinase
Gene Name	PFKM
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
652	FDRNFATKMGAKAMN

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MTHEEHHAAK 20 SLGVGKAIAV 30 LTSGGDAQGM 40 NAAVRAVVRV 50 GIYTGARVFF 60 VHEGGTVIGS 70 ARCKDFRERE 80 GRLRAAHNLV 90 KRGITNLCVI 100 GGDGSLTGAD 110 TFRSEWGDLL 120 NDLQKAGKIT 130 AEEANKSSYL 140 NIVGLVGSID 150 NDFCGTDMTI 160 GTDSALHRII 170 EIVDAITTTA 180 QSHQRTFVLE 190 VMGRHCGYLA 200 LVTSLSCGAD 210 WVFIPECPPD 220 DAWEEHLCRR 230 LSETRTRGSR 240 LNIIIVAEGA 250 IDKNGQPITS 260 ENIKDLVVKR 270 LGYDTRVTVL 280 GHVQRGGTPS 290 AFDRILGSRM 300 GVEAVMALLE 310 GTPDTPACVV 320 SLSGNQAVRL 330 PLMECVQVTK 340 DVTKAMNEKR 350 FDEAMKLRGR 360 SFMNNWEVYK 370 LLAHVRPPVT 380 KSGSYTVAVM 390 NVGAPAAGMN 400 AAVRSTVRIG 410 LIQGNRVLVV 420 HDGFEGLAKG 430 QIEEAGWSYV 440 GGWTGQGGSK 450 LGTKRTLPKK 460 SFEQISANIT 470 KFNIQGLVII 480 GGFEAYTGGL 490 ELMEGRKQYD 500 ELCIPFVVIP 510 ATVSNNVPGS 520 DFSVGADTAL 530 NTICMTCDRI 540 KQSAAGTKRR 550 VFIIETMGGY 560 CGYLATMAGL 570 AAGADAAYIF 580 EEPFTIRDLQ 590 VNVEHLVQKM 600 KTTVKRGLVL 610 RNEKCNENYT 620 TDFIFNLYSE 630 EGKGIFDSRK 640 NVLGHMQQGG 650 SPTPFDRNFA 660 TKMGAKAMNW 670 MSGKIKESYR 680 NGRIFANTPD 690 SGCVLGMRKR 700 ALVFQPVTEL 710 KEQTDFEHRI 720 PKEQWWLKLR 730 PILKILAKYE 740 IDLDTSEHAH 750 LEHITRKRSG EATI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0003872	6-phosphofructokinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006002	fructose 6-phosphate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.