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Overview

Uniprot IDA0A287B880
Protein NameNuclear protein localization protein 4 homolog
Gene NameNPLOC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
173 VQSPDGVKRITATKR
188 ETAATFLKKVAKEFG
209 SVYINRNKTGEIPAS
225 NKSLNLLKIKHGDLL
277 FLSRQDGKIYRSRDP
342 TGGADKGKFVALENI
352 ALENISCKIKSGCEG
406 RFLDFWRKTGNQHFG
423 YGRYTEHKDIPLGIR

Function

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI

Protein Sequence

10 MLSLKYVCIS 20 SRCDVTFSSL 30 SPFPCDQVSG 40 TPGRADAPGP 50 ADLSAASLPR 60 VASGGARLRG 70 AQGAGGRAAQ 80 ARTVGGAGTR 90 CAAGTQLRGR 100 GARGARRARH 110 RTSRRWLPAA 120 KLERRWRRRR 130 EAGAGAEAGA 140 GAARPAGRQA 150 AAAAAARGSS 160 PETGAAAMAE 170 SIIIRVQSPD 180 GVKRITATKR 190 ETAATFLKKV 200 AKEFGFQNNG 210 FSVYINRNKT 220 GEIPASSNKS 230 LNLLKIKHGD 240 LLFLFPSSLA 250 GPSAEMETSA 260 PLALKACGAP 270 NVVEDDIDQF 280 LSRQDGKIYR 290 SRDPQPIRLG 300 PSARCGGGGV 310 TVDRLSWQPF 320 DEDYLNHLEP 330 PVKHMSFHAY 340 IRKLTGGADK 350 GKFVALENIS 360 CKIKSGCEGH 370 LPWPNGICTK 380 CQPSAITLNR 390 QKYRHVDNIM 400 FENHTVADRF 410 LDFWRKTGNQ 420 HFGYLYGRYT 430 EHKDIPLGIR 440 AEVAAIYEPP 450 QIGTQNSLEL 460 LEDPKAEVVD 470 EIAAKLGLRK 480 VGWIFTDLVS 490 EDARKGTVRY 500 SRNKDTYFLS 510 SEECITAGDF 520 QNKHPNVCRL 530 SPDGHFGSKF 540 VTAVATGGPD 550 NQVHFEGYQV 560 SNQCMALVRD 570 ECLLPCKDAP 580 ELGYAKESSS 590 EQYVPDVFYK 600 DIDKFGNEIT 610 QLARPLPVEY 620 LIIDITTTFP 630 KDPVYTFSIS 640 QNPFPIENRD 650 VLGETQDFHS 660 LATYLSQSTS 670 SVFLDTVSDF 680 HLLLFLVTND 690 VMPLQDSISL 700 LLEAVRTRNE 710 ELAQTWKKSE 720 QWATIEQLCS 730 TVGVQLPGLQ 740 EYGAVGGPTH 750 AASAAMWACQ 760 HCTFMNQPGT 770 GHCEMCSLPR T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030970 retrograde protein transport, ER to cytosol
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.