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Overview

Uniprot IDA0A287B893
Protein NamePre-rRNA-processing protein TSR1 homolog
Gene NameTSR1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
10 AHRSGPLKQQNKAHK
38 GKGRLALKTLSKKVR
542 NTRRRIFKEIEEKEV

Function

Required during maturation of the 40S ribosomal subunit in the nucleolus

Protein Sequence

10 MAAHRSGPLK 20 QQNKAHKGGR 30 HRGRGSAQRD 40 GKGRLALKTL 50 SKKVRKDLSR 60 VDQRHRASQL 70 RKQKKEAVLA 80 EKRQLGSKDG 90 PPHQVLVVPL 100 HSRVSLPEAF 110 RLLQDRDTGT 120 VHLKEWGSTH 130 SFMLLCPRLK 140 HRWFFTSARP 150 GDLHTVLDMA 160 KVADTILFLL 170 DPLEGWDSTG 180 DYCLSCLFAQ 190 GLPTYTLAVQ 200 GVSGLPPKKQ 210 TDARKKLSKA 220 VEKRFPDDKL 230 LLLDTQQEAG 240 MLLRQLANQK 250 QRHLAFRDRR 260 AYLFAHAADF 270 VPSEENNLVG 280 TLKISGYVRG 290 QALNVNSLLH 300 IIGHGDFQMQ 310 QIDAPMDPFP 320 LNPRVIKSPK 330 DPDMAMEICA 340 ADAVADMEED 350 LKVLMKADPD 360 KQESLLTEVI 370 PDPMEGEQTW 380 PTEEELSEAQ 390 DLLKESSKVV 400 KKVPKGTSAY 410 QAEWILDEDG 420 ESGGEGDEYD 430 DIEHEDFMEE 440 DSQDEGSEKE 450 EEEECETMTV 460 GESERDDLYD 470 EKVDEEVEEK 480 MLEKYKQERL 490 EEMFPDEVDT 500 PRDVAARIRF 510 QKYRGLKSFR 520 TSPWDPKENL 530 PPDYARIFQF 540 QNFLNTRRRI 550 FKEIEEKEVE 560 GAEVGWYVTL 570 HVSEVPVSVV 580 EHFKRGAPLI 590 AFSLLPHEQK 600 MSVLNMVVSR 610 HPGNTEPIKA 620 KEELIFHCGF 630 RRFRASPLFS 640 QHTAADKHKF 650 QRFLTADMAL 660 VVTVYAPITF 670 PPASVLLFKQ 680 NSNGMHSLIA 690 TGHLLSVDPD 700 RMVIKRVVLS 710 GHPFKIFTKM 720 AVVRYMFFSR 730 EDVLWFKPVE 740 LRTKWGRRGY 750 IKEPLGTHGH 760 MKCSFDGKLK 770 SQDTVLMNLY 780 KRVFPKWTYD 790 PYVPDPVPWV 800 KNEISSTVPE EDME

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030686 90S preribosome
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.