Overview
| Uniprot ID | A0A287B8F3 |
|---|
| Protein Name | Fructose-bisphosphate aldolase |
|---|
| Gene Name | ALDOA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 151 |
RPFPQVIKAKGGVVG |
| 153 |
FPQVIKAKGGVVGIK |
| 160 |
KGGVVGIKVDKGVVP |
| 163 |
VVGIKVDKGVVPLAG |
| 192 |
ERCAQYKKDGADFAK |
| 199 |
KDGADFAKWRCVLKI |
| 260 |
RCQYVTEKVLAAVYK |
| 282 |
YLEGTLLKPNMVTPG |
| 364 |
ALQASALKAWGGKKE |
| 374 |
GGKKENLKAAQEEYV |
| 382 |
AAQEEYVKRALANSL |
| 394 |
NSLACQGKYTPSGKA |
| 400 |
GKYTPSGKAGAAASE |
| 66 |
ALTPEQKKELSDIAH |
| 80 |
HRIVAPGKGILAADE |
| 94 |
ESTGSIAKRLQSIGT |
Function
Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check
Protein Sequence
10
MAKREPQGSG
20
FHMTGLSMVL
30
AYSFTPDASV
40
QPHPQLGHAQ
50
QQTELGKELT
60
GTMPHQYPAL
70
TPEQKKELSD
80
IAHRIVAPGK
90
GILAADESTG
100
SIAKRLQSIG
110
TENTEENRRF
120
YRQLLLTADD
130
RVNPCIGGVI
140
LFHETLYQKA
150
DDGRPFPQVI
160
KAKGGVVGIK
170
VDKGVVPLAG
180
TNGETTTQGL
190
DGLSERCAQY
200
KKDGADFAKW
210
RCVLKIGEHT
220
PSSLAIMENA
230
NVLARYASIC
240
QQNGIVPIVE
250
PEILPDGDHD
260
LKRCQYVTEK
270
VLAAVYKALS
280
DHHIYLEGTL
290
LKPNMVTPGH
300
ACTQKYSHEE
310
IAMATVTALR
320
RTVPPAVPGI
330
TFLSGGQSEE
340
EASINLNAIN
350
KCPLLKPWAL
360
TFSYGRALQA
370
SALKAWGGKK
380
ENLKAAQEEY
390
VKRALANSLA
400
CQGKYTPSGK
410
AGAAASESLF
ISNHAY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034451 |
centriolar satellite |
| Molecular Function |
GO:0004332 |
fructose-bisphosphate aldolase activity |
| Biological Process |
GO:0006096 |
glycolytic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.