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Overview

Uniprot IDA0A287B8N1
Protein NameATP-dependent 6-phosphofructokinase
Gene NamePFKM
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
748 FDRNFATKMGAKAMN

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MHKEEVHLKF 20 FMCVIQSRQL 30 VRTPQRTAGE 40 ASTSSLLIQK 50 SPKTDTLKSL 60 DTMDDPHTVE 70 GIHVFENEWI 80 MTHEEHHAAK 90 SLGVGKAIAV 100 LTSGGDAQGM 110 NAAVRAVVRV 120 GIYTGARVFF 130 VHEGYQGLVD 140 GGDNIREATW 150 ESVSMMLQLG 160 GTVIGSARCK 170 DFREREGRLR 180 AAHNLVKRGI 190 TNLCVIGGDG 200 SLTGADTFRS 210 EWGDLLNDLQ 220 KAGKITAEEA 230 NKSSYLNIVG 240 LVGSIDNDFC 250 GTDMTIGTDS 260 ALHRIIEIVD 270 AITTTAQSHQ 280 RTFVLEVMGR 290 HCGYLALVTS 300 LSCGADWVFI 310 PECPPDDAWE 320 EHLCRRLSET 330 RTRGSRLNII 340 IVAEGAIDKN 350 GQPITSENIK 360 DLVVKRLGYD 370 TRVTVLGHVQ 380 RGGTPSAFDR 390 ILGSRMGVEA 400 VMALLEGTPD 410 TPACVVSLSG 420 NQAVRLPLME 430 CVQVTKDVTK 440 AMNEKRFDEA 450 MKLRGRSFMN 460 NWEVYKLLAH 470 VRPPVTKSGS 480 YTVAVMNVGA 490 PAAGMNAAVR 500 STVRIGLIQG 510 NRVLVVHDGF 520 EGLAKGQIEE 530 AGWSYVGGWT 540 GQGGSKLGTK 550 RTLPKKSFEQ 560 ISANITKFNI 570 QGLVIIGGFE 580 AYTGGLELME 590 GRKQYDELCI 600 PFVVIPATVS 610 NNVPGSDFSV 620 GADTALNTIC 630 MTCDRIKQSA 640 AGTKRRVFII 650 ETMGGYCGYL 660 ATMAGLAAGA 670 DAAYIFEEPF 680 TIRDLQVNVE 690 HLVQKMKTTV 700 KRGLVLRNEK 710 CNENYTTDFI 720 FNLYSEEGKG 730 IFDSRKNVLG 740 HMQQGGSPTP 750 FDRNFATKMG 760 AKAMNWMSGK 770 IKESYRNGRI 780 FANTPDSGCV 790 LGMRKRALVF 800 QPVTELKEQT 810 DFEHRIPKEQ 820 WWLKLRPILK 830 ILAKYEIDLD 840 TSEHAHLEHI 850 TRKRSGEATI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005945 6-phosphofructokinase complex
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0030388 fructose 1,6-bisphosphate metabolic process
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0097228 sperm principal piece
Molecular Function GO:0003872 6-phosphofructokinase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0070061 fructose binding
Molecular Function GO:0070095 fructose-6-phosphate binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0046872 metal ion binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.