Search Results
Overview
| Uniprot ID | A0A287B8R9 |
|---|---|
| Protein Name | Zinc finger CCCH domain-containing protein 14 |
| Gene Name | ZC3H14 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | VSSTRPEKRDSRVST |
| 307 | SSVVKVKKFNHDGEE |
| 352 | PPSKQANKNLILKAI |
| 533 | RYFPACKKMECPFYH |
| 571 | VPPRHALKWIRPQTS |
Function
RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells
Protein Sequence
10
MEIGTEISRK
20
IRSAIKGKLQ
30
ELGAYVDEEL
40
PDYIMVMVAN
50
KKSQDQMTED
60
LSLFLGNNTI
70
RFTVWLHGVL
80
DKLRSVTTDP
90
SSFKSSDTNI
100
FDSNVPSNKS
110
SFSRGDERRH
120
EAAVPPLAVS
130
STRPEKRDSR
140
VSTSSQEQKA
150
TNVRQTYDDG
160
AATRLMSTVK
170
PLREPAPSED
180
VIDIKPEPDD
190
LIDEDLNFVQ
200
ENPLSQKKPT
210
VTLTYGSSRP
220
SIEIYRPPAS
230
RNADSGAHLN
240
RLQFQQQQNS
250
IHAAKQVDIQ
260
SSRVYETGRL
270
CEPEVLNSLE
280
ETYSPFFRNN
290
SEKMSIEEEN
300
FRKRKLPVVS
310
SVVKVKKFNH
320
DGEEEEEEDD
330
CGSRTGSISS
340
SVSVPAKPER
350
RPSLPPSKQA
360
NKNLILKAIS
370
EAQESVTKTT
380
NYSTVSQKQT
390
LPVAPRTRTS
400
QEELLAEMVQ
410
GQSKAPRISS
420
PIKEEETKGD
430
NIDKSQAEMS
440
ELSVAQKPEK
450
LLERCKYWPA
460
CKNGDECAYH
470
HPISPCKAFP
480
NCKFAEKCLF
490
VHPNCKYDAK
500
CTKPDCPFTH
510
MSRRIPVLPP
520
KPVTTPAPPS
530
SSQLCRYFPA
540
CKKMECPFYH
550
PKHCRFNTQC
560
TRPDCTFYHP
570
TITVPPRHAL
KWIRPQTSE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Molecular Function | GO:0008143 | poly(A) binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.