Search Results

Overview

Uniprot IDA0A287B9W3
Protein NameCytoplasmic dynein 1 heavy chain 1
Gene NameDYNC1H1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1097 TFDNAETKKEFGPVV
1098 FDNAETKKEFGPVVI
1123 LKYDSWHKEVLSKFG
1183 RKIKQFEKQVELYRN
129 APVIDADKPVSSQLR
1389 EFVQRLLKGYLKINM
1407 ELKSEALKDRHWKQL
1607 RLADLLGKIQKALGE
1610 DLLGKIQKALGEYLE
1684 EGEEVTFKTPVSITE
1804 QPPLRRRKLEHLITE
1914 TGKTESVKALGHQLG
1989 HSSPNHDKASAPITC
2001 ITCELLNKQVKVSPD
2030 SNLPDNLKKLFRSLA
2091 DFGLRALKSVLVSAG
2101 LVSAGNVKRERIQKI
2238 MAWRVLLKALERLEG
2256 VAHIIDPKAISKDHL
2260 IDPKAISKDHLYGTL
2965 YQIKVHRKYTGEDFD
3231 KSQELEVKNAAANDK
3300 NAVKSIKKQHLVEVR
3423 QKLEDDAKDNQQKAN
3470 DLAAVEAKVNRSTAL
3479 NRSTALLKSLSAERE
3490 AERERWEKTSETFKN
371 LRKIRNTKYPIQRAL
3717 QCLNEVLKAERPDVD
3726 ERPDVDEKRSDLLKL
3911 FQHFLRGKEIVLSAG
4088 KAINTAVKSGRWVML
4170 VPVSRICKSPNERAR
4203 APLGWSKKYEFGESD
4284 RSFDSEFKLACKVDG
4407 KRTVDNIKDPLFRFF
4442 VVQVCEGKKKQTNYL
4444 QVCEGKKKQTNYLRT
4488 SDFSERIKQLQSVSQ
4503 AAASGGAKELKNIHV
4595 LTQLRWVKQTNAEKK
613 TQLIQRVKDDIESLH
624 ESLHDKFKVQYPQSQ
67 SALEQMRKFLSDPQV
683 HVEGQKLKQDGDSFR
734 GRSGNVLKLKVNFLP
754 SKEVRNLKWLGFRVP
794 TYERTCEKVEERNTI
954 PGGEPKIKNVVHELR

Function

Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression

Protein Sequence

10 MSEPGGGGGE 20 DGSAGLEVSA 30 VQNVADVSVL 40 QKHLRKLVPL 50 LLEDGGEAPA 60 ALEAALEEKS 70 ALEQMRKFLS 80 DPQVHTVLVE 90 RSTLKEDVGD 100 EGEEEKEFIS 110 YNINIDIHYG 120 VKSNSLAFIK 130 RAPVIDADKP 140 VSSQLRVLTL 150 SEDSPYETLH 160 SFISNAVAPF 170 FKSYIRESGK 180 ADRDGDKMAP 190 SVEKKIAELE 200 MGLLHLQQNI 210 EIPEISLPIH 220 PIITNVAKQC 230 YERGEKPKVT 240 DFGDKVEDPT 250 FLNQLQSGVN 260 RWIREIQKVT 270 KLDRDPASGT 280 ALQEISFWLN 290 LERALYRIQE 300 KRESPEVLLT 310 LDILKHGKRF 320 HATVSFDTDT 330 GLKQALETVN 340 DYNPLMKDFP 350 LNDLLSATEL 360 DKIRQALVAI 370 FTHLRKIRNT 380 KYPIQRALRL 390 VEAISRDLSS 400 QLLKVLGTRK 410 LMHVAYEEFE 420 KVMVACFEVF 430 QTWDDEYEKL 440 QVLLRDIVKR 450 KREENLKMVW 460 RINPAHRKLQ 470 ARLDQMRKFR 480 RQHEQLRAVI 490 VRVLRPQVTA 500 VAQQNQGEAP 510 EPQDMKVAEV 520 LFDAADANAI 530 EEVNLAYENV 540 KEVDGLDVSK 550 EGTEAWEAAM 560 KRYDERIDRV 570 ETRITARLRD 580 QLGTAKNANE 590 MFRIFSRFNA 600 LFVRPHIRGA 610 IREYQTQLIQ 620 RVKDDIESLH 630 DKFKVQYPQS 640 QACKMSHVRD 650 LPPVSGSIIW 660 AKQIDRQLTA 670 YMKRVEDVLG 680 KGWENHVEGQ 690 KLKQDGDSFR 700 MKLNTQEIFD 710 DWARKVQQRN 720 LGVSGRIFAI 730 ESTRVRGRSG 740 NVLKLKVNFL 750 PEIITLSKEV 760 RNLKWLGFRV 770 PLAIVNKAHQ 780 ANQLYPFAIS 790 LIESVRTYER 800 TCEKVEERNT 810 ISLLVAGLKK 820 EVQALIAEGI 830 ALVWESYKLD 840 PYVQRETVFN 850 FQEKVDDLLI 860 IEEKIDLEVR 870 SLETCVYDHK 880 TFSEILNRVQ 890 KAVDDLNLHS 900 YSNLPIWVNK 910 LDMEIERILG 920 VRLQAGLRAW 930 TQVLLGQAED 940 KAEVDMDTDA 950 PQVSHKPGGE 960 PKIKNVVHEL 970 RITNQVIYLN 980 PPIEECRYKL 990 YQEMFAWKMV 1000 VLSLPRIQSQ 1010 RYQVGVHYEL 1020 TEEEKFYRNA 1030 LTRMPDGPVA 1040 LEESYSAVMG 1050 IVTEVEQYVK 1060 VWLQYQCLWD 1070 MQAENIYNRL 1080 GEDLNKWQAL 1090 LVQIRKARGT 1100 FDNAETKKEF 1110 GPVVIDYGKV 1120 QSKVNLKYDS 1130 WHKEVLSKFG 1140 QMLGSNMTEF 1150 HSQISKSRQE 1160 LEQHSVDTAS 1170 TSDAVTFITY 1180 VQSLKRKIKQ 1190 FEKQVELYRN 1200 GQRLLEKQRF 1210 QFPPSWLYID 1220 NIEGEWGAFN 1230 DIMRRKDSAI 1240 QQQVANLQMK 1250 IVQEDRAVES 1260 RTTDLLADWE 1270 KTKPVTGNLR 1280 PEEALQALTI 1290 YEGKFGRLKD 1300 DREKCAKAKE 1310 ALELTETGLL 1320 SGSEERVQVA 1330 LEELQDLKGV 1340 WSELSKIWEQ 1350 IDQMKEQPWV 1360 SVQPRKLRQN 1370 LDGLLNQLKN 1380 FPARLRQYAS 1390 YEFVQRLLKG 1400 YLKINMLVIE 1410 LKSEALKDRH 1420 WKQLMKRLHV 1430 NWVVSELTLG 1440 QIWDVDLQKN 1450 EAVVKDVLLV 1460 AQGEMALEEF 1470 LKQAKVWNTY 1480 ELDLVNYQNK 1490 CRLIRGWDDL 1500 FNKVKEHINS 1510 VSAMKLSPYY 1520 KVFEEDALSW 1530 EDKLNRIMAL 1540 FDVWIDVQRR 1550 WVYLEGIFTG 1560 SADIKHLLPV 1570 ETQRFQSIST 1580 EFLALMKKVS 1590 KSPLVMDVLN 1600 IQGVQRSLER 1610 LADLLGKIQK 1620 ALGEYLERER 1630 SSFPRFYFVG 1640 DEDLLEIIGN 1650 SKNVAKLQKH 1660 FKKMFAGVSS 1670 IILSEDNSVV 1680 LGISSREGEE 1690 VTFKTPVSIT 1700 EHPKINEWLT 1710 LVEKEMRVTL 1720 AKLLAESVTE 1730 VEIFGKATSI 1740 DPNTYITWID 1750 KYQAQLVVLS 1760 AQIAWSENVE 1770 AALSSIGGSG 1780 DSAPLQSVLS 1790 NVEVTLNVLA 1800 DSVLMEQPPL 1810 RRRKLEHLIT 1820 ELVHQRDVTR 1830 SLIKSKIDNA 1840 KSFEWLSQMR 1850 FYFDPKQTDV 1860 LQQLSIQMAN 1870 AKFNYGFEYL 1880 GVQDKLVQTP 1890 LTDRCYLTMT 1900 QALEARLGGS 1910 PFGPAGTGKT 1920 ESVKALGHQL 1930 GRFVLVFNCD 1940 ETFDFQAMGR 1950 IFVGLCQVGA 1960 WGCFDEFNRL 1970 EERMLSAVSQ 1980 QVQCIQEALR 1990 EHSSPNHDKA 2000 SAPITCELLN 2010 KQVKVSPDMA 2020 IFITMNPGYA 2030 GRSNLPDNLK 2040 KLFRSLAMTK 2050 PDRQLIAQVM 2060 LYSQGFRTAE 2070 VLANKIVPFF 2080 KLCDEQLSSQ 2090 SHYDFGLRAL 2100 KSVLVSAGNV 2110 KRERIQKIKR 2120 EKEERGEAVD 2130 EGEIAENLPE 2140 QEILIQSVCE 2150 TMVPKLVAED 2160 IPLLFSLLSD 2170 VFPGVQYHRG 2180 EMTALREELK 2190 KVCQEMYLTY 2200 GDGEEVGGMW 2210 VEKASVLQLY 2220 QITQINHGLM 2230 MVGPSGSGKS 2240 MAWRVLLKAL 2250 ERLEGVEGVA 2260 HIIDPKAISK 2270 DHLYGTLDPN 2280 TREWTDGLFT 2290 HVLRKIIDNV 2300 RGELQKRQWI 2310 VFDGDVDPEW 2320 VENLNSVLDD 2330 NKLLTLPNGE 2340 RLSLPPNVRI 2350 MFEVQDLKYA 2360 TLATVSRCGM 2370 VWFSEDVLST 2380 DMIFNNFLAR 2390 LRSIPLDEGE 2400 DEAQRRRKGK 2410 EDEGEEAASP 2420 MLQIQRDAAT 2430 TLQPYFTPNG 2440 LVTKALEHAF 2450 KLEHIMDLTR 2460 LRCLGSLFSM 2470 LHQACRNVAQ 2480 YNANHPDFPM 2490 QMEQLERYIQ 2500 RYLVYAILWS 2510 LSGDSRLKMR 2520 AELGEYIRRI 2530 TTVPLPAAPN 2540 IPIIDYEVSI 2550 SGEWSPWQAK 2560 VPQIEVETHK 2570 VAAPDVVVPT 2580 LDTVRHEALL 2590 YTWLAEHKPL 2600 VLCGPPGSGK 2610 TMTLFSALRA 2620 LPDMEVVGLN 2630 FSSATTPELL 2640 LKTFDHYCEY 2650 RRTPNGVVLA 2660 PVQLGKWLVL 2670 FCDEINLPDM 2680 DKYGTQRVIS 2690 FIRQMVEHGG 2700 FYRTSDQTWV 2710 KLERIQFVGA 2720 CNPPTDPGRK 2730 PLSHRFLRHV 2740 PVVYVDYPGP 2750 ASLTQIYGTF 2760 NRAMLRLVPS 2770 LRTYAEPLTA 2780 AMVEFYTMSQ 2790 ERFTQDTQPH 2800 YIYSPREMTR 2810 WVRGIFEALR 2820 PLETLPVEGL 2830 IRIWAHEALR 2840 LFQDRLVEDE 2850 ERRWTDENID 2860 LVALKHFPNI 2870 DKEKAMSRPI 2880 LYSNWLSKDY 2890 IPVDQEELRD 2900 YVKARLKVFY 2910 EEELDVPLVL 2920 FNEVLDHVLR 2930 IDRIFRQPQG 2940 HLLLIGVSGA 2950 GKTTLSRFVA 2960 WMNGLSVYQI 2970 KVHRKYTGED 2980 FDEDLRTVLR 2990 RSGCKNEKIA 3000 FIMDESNVLD 3010 SGFLERMNTL 3020 LANGEVPGLF 3030 EGDEYATLMT 3040 QCKEGAQKEG 3050 LMLDSHEELY 3060 KWFTSQVIRN 3070 LHVVFTMNPS 3080 SEGLKDRAAT 3090 SPALFNRCVL 3100 NWFGDWSTEA 3110 LYQVGKEFTS 3120 KMDLEKPNYV 3130 VPDYMPVVYD 3140 KLPQPPSHRE 3150 AIVNSCVFVH 3160 QTLHQANARL 3170 AKRGGRTMAI 3180 TPRHYLDFIN 3190 HYANLFHEKR 3200 SELEEQQMHL 3210 NVGLRKIKET 3220 VDQVEELRRD 3230 LRIKSQELEV 3240 KNAAANDKLK 3250 KMVKDQQEAE 3260 KKKVMSQEIQ 3270 EQLHKQQEVI 3280 ADKQMSVKED 3290 LDKVEPAVIE 3300 AQNAVKSIKK 3310 QHLVEVRSMA 3320 NPPAAVKLAL 3330 ESICLLLGES 3340 TTDWKQIRSI 3350 IMRENFIPTI 3360 VNFSAEEISD 3370 AIREKMKKNY 3380 MSNPSYNYEI 3390 VNRASLACGP 3400 MVKWAIAQLN 3410 YADMLKRVEP 3420 LRNELQKLED 3430 DAKDNQQKAN 3440 EVEQMIRDLE 3450 ASIARYKEEY 3460 AVLISEAQAI 3470 KADLAAVEAK 3480 VNRSTALLKS 3490 LSAERERWEK 3500 TSETFKNQMS 3510 TIAGDCLLSA 3520 AFIAYAGYFD 3530 QQMRQNLFTT 3540 WSHHLQQANI 3550 QFRTDIARTE 3560 YLSNADERLR 3570 WQASSLPADD 3580 LCTENAIMLK 3590 RFNRYPLIID 3600 PSGQATEFIM 3610 NEYKDRKITR 3620 TSFLDDAFRK 3630 NLESALRFGN 3640 PLLVQDVESY 3650 DPVLNPVLNR 3660 EVRRTGGRVL 3670 ITLGDQDIDL 3680 SPSFVIFLST 3690 RDPTVEFPPD 3700 LCSRVTFVNF 3710 TVTRSSLQSQ 3720 CLNEVLKAER 3730 PDVDEKRSDL 3740 LKLQGEFQLR 3750 LRQLEKSLLQ 3760 ALNEVKGRIL 3770 DDDTIITTLE 3780 NLKREAAEVT 3790 RKVEETDIVM 3800 QEVETVSQQY 3810 LPLSTACSSI 3820 YFTMESLKQI 3830 HFLYQYSLQF 3840 FLDIYHNVLY 3850 ENPNLKGVTD 3860 HTQRLCIITK 3870 DLFQVAFNRV 3880 ARGMLHQDHI 3890 TFAMLLARIK 3900 LKGTVGEPTY 3910 EAEFQHFLRG 3920 KEIVLSAGST 3930 PKIPGLTVEQ 3940 AEAVVRLSCL 3950 PAFKDLIAKV 3960 QADEQFSIWL 3970 DSSSPEQTVP 3980 HLWSEENPAT 3990 PIGQAIHRLL 4000 LIQAFRPDRL 4010 LAMAHVFVST 4020 NLGESFMSIM 4030 EQPLDLTHIV 4040 DTEVKPNTPV 4050 LMCSVPGYDA 4060 SGHVEDLAAE 4070 QNTQITSIAI 4080 GSAEGFNQAD 4090 KAINTAVKSG 4100 RWVMLKNVHL 4110 APGWLMQLEK 4120 KLHSLQPHAC 4130 FRLFLTMEIN 4140 PKVPVNLLRA 4150 GRIFVFEPPP 4160 GVKANMLRTF 4170 SSVPVSRICK 4180 SPNERARLYF 4190 LLAWFHAIIQ 4200 ERLRYAPLGW 4210 SKKYEFGESD 4220 LRSACDTVDT 4230 WLDDTAKAGG 4240 RQNISPDKIP 4250 WSALKTLMAQ 4260 SIYGGRVDNE 4270 FDQRLLNTFL 4280 ERLFTTRSFD 4290 SEFKLACKVD 4300 GHKDIQMPDG 4310 IRREEFVQWV 4320 ELLPDTQTPS 4330 WLGLPNNAER 4340 VLLTTQGVDM 4350 ISKMLKMQML 4360 EDEDDLAYAE 4370 TEKKTRTDST 4380 ADGRPAWMRT 4390 LHTTASNWLH 4400 LIPQTLSHLK 4410 RTVDNIKDPL 4420 FRFFEREVKM 4430 GARLLQDVRQ 4440 DLADVVQVCE 4450 GKKKQTNYLR 4460 TLINELVKGI 4470 LPRSWSHYTV 4480 PAGMTVIQWV 4490 SDFSERIKQL 4500 QSVSQAAASG 4510 GAKELKNIHV 4520 CLGGLFVPEA 4530 YITATRQYVA 4540 QANSWSLEEL 4550 CLEVIVTTSQ 4560 SATLDACSFG 4570 VTGLKLQGAT 4580 CSNNKLSLSN 4590 AISTVLPLTQ 4600 LRWVKQTNAE 4610 KKANVVTLPV 4620 YLNFTRADLI 4630 FTVDFEIATK 4640 EDPRSFYERG VAVLCTE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005868 cytoplasmic dynein complex
Cellular Component GO:0005881 cytoplasmic microtubule
Cellular Component GO:0030175 filopodium
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0051301 cell division
Biological Process GO:0040001 establishment of mitotic spindle localization
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0007097 nuclear migration
Biological Process GO:0033962 P-body assembly
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0032388 positive regulation of intracellular transport
Biological Process GO:1905832 positive regulation of spindle assembly
Biological Process GO:0090235 regulation of metaphase plate congression
Biological Process GO:0060236 regulation of mitotic spindle organization
Biological Process GO:0034063 stress granule assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.