Search Results

Overview

Uniprot IDA0A287BA08
Protein NameMethylmalonyl-CoA mutase, mitochondrial
Gene NameMMUT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
465 AVAEGIPKLRIEECA

Function

Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle

Protein Sequence

10 MLRAKTRLFL 20 LSPHHLKQLK 30 KSSGSRLVWQ 40 RLLHQQQPLH 50 PEWAALAKKQ 60 LKGKNPEELI 70 WHTPEGISIK 80 PLYSSRDTKD 90 FPEELPGVKP 100 FTRGPYPTMY 110 TFRPWTIRQY 120 AGFSTVEESN 130 KFYKDNIKAG 140 QQGLSVAFDL 150 ATHRGYDSDN 160 PRVRGDVGMA 170 GVAIDTVEDT 180 KILFDGIPLE 190 KMSVSMTMNG 200 AVIPVLATFI 210 VSGEEQGVPK 220 EKLTGTIQND 230 ILKEFMVRNT 240 YIFPPEPSMK 250 IIADIFQYTA 260 KHMPKFNSIS 270 ISGYHMQEAG 280 ADAILELAYT 290 IADGLEYCRT 300 GLQAGLTIDE 310 FAPRLSFFWG 320 IGMNFYMEIA 330 KMRAGRRLWA 340 HLIEKMFRPK 350 NSKSLLLRAH 360 CQTSGWSLTE 370 QDPYNNIIRT 380 TVEAMAAVFG 390 GTQSLHTNSF 400 DEALGLPTVK 410 SARIARNTQI 420 IIQEESGIPK 430 VADPWGGSYM 440 MESLTNDVYD 450 AALKLINEIE 460 EMGGMAKAVA 470 EGIPKLRIEE 480 CAARRQARID 490 SGSEVIVGVN 500 KYQLEKEESV 510 EVLAIDNTSV 520 RNKQIEKLKK 530 VKSSRDQALA 540 ERCLTALTAC 550 AASGDGNILA 560 LAVEATRARC 570 TVGEITDAMK 580 KVFGEHKAND 590 RMVSGAYRQE 600 FGESKEISFA 610 IKRVHKFMER 620 EGRRPRLLVA 630 KMGQDGHDRG 640 AKVIATGFAD 650 LGFDVDIGPL 660 FQTPREVAQQ 670 AVDADVHAVG 680 VSTLAAGHKT 690 LVPELIKELS 700 TLGRPDILVI 710 CGGVIPPQDY 720 EFLFEVGVSN 730 VFGPGTRIPK 740 AAVQVLNDIE 750 KCLEKKQQSM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0031419 cobalamin binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004494 methylmalonyl-CoA mutase activity
Molecular Function GO:0072341 modified amino acid binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0050667 homocysteine metabolic process
Biological Process GO:0019678 propionate metabolic process, methylmalonyl pathway
Biological Process GO:1901290 succinyl-CoA biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.