Search Results
Overview
| Uniprot ID | A0A287BA45 |
|---|---|
| Protein Name | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial |
| Gene Name | SUCLG2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | GVFSSGLKGGVHLTK |
| 108 | KGGVHLTKDPEVVGQ |
| 291 | PIENEAAKYDLKYIG |
| 78 | AAKRLNAKEIVLKAQ |
| 93 | ILAGGRGKGVFSSGL |
Function
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase
Protein Sequence
10
MAAPVAAQAR
20
KLLRDLAFRP
30
PLLAARSQVV
40
QLTPRRWLNL
50
QEYQSKKLMS
60
DNGVKVQRFF
70
VADTANEALE
80
AAKRLNAKEI
90
VLKAQILAGG
100
RGKGVFSSGL
110
KGGVHLTKDP
120
EVVGQLAKQM
130
IGYNLATKQT
140
PKEGVKVNKV
150
MVAEALDISR
160
ETYLAILMDR
170
SCNGPVLVGS
180
PQGGVDIEEV
190
AASNPELIFK
200
EQIDIIEGIK
210
DSQAQRMAEN
220
LGFLGPLQNQ
230
AADQIKKLYN
240
LFLKIDATQV
250
EVNPFGETPE
260
GQVVCFDAKI
270
NFDDNAEFRQ
280
KDIFAMDDKS
290
ENEPIENEAA
300
KYDLKYIGLD
310
GNIACFVNGA
320
GLAMATCDII
330
FLNGGKPANF
340
LDLGGGVKES
350
QVYQAFKLLT
360
ADPKVEAILV
370
NIFGGIVNCA
380
IIANGITKAC
390
RELELKVPLV
400
VRLEGTNVHE
410
AQNILTNSGL
420
PITSAVDLED
430
AAKKAVASVT
KK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0042709 | succinate-CoA ligase complex |
| Cellular Component | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Biological Process | GO:0006104 | succinyl-CoA metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.