Overview
| Uniprot ID | A0A287BA60 |
|---|
| Protein Name | Ran-specific GTPase-activating protein |
|---|
| Gene Name | RANBP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 150 |
LNAENAQKFKTKFEE |
| 154 |
NAQKFKTKFEECRKE |
| 178 |
GKNDSAEKVAEKLEA |
| 182 |
SAEKVAEKLEALSVK |
| 189 |
KLEALSVKAGTEPQD |
| 68 |
ENDLPEWKERGTGDV |
| 76 |
ERGTGDVKLLKHKEK |
Function
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP
Protein Sequence
10
MAAAKDTHED
20
HDTSTENADE
30
SNHDPQFEPI
40
VSLPEQEIKT
50
LEEDEEELFK
60
MRAKLFRFAS
70
ENDLPEWKER
80
GTGDVKLLKH
90
KEKGTIRLLM
100
RRDKTLKICA
110
NHYITPMMEL
120
KPNAGSDRAW
130
VWNTHADFAD
140
ECPKQELLAI
150
RFLNAENAQK
160
FKTKFEECRK
170
EIEEREKKGS
180
GKNDSAEKVA
190
EKLEALSVKA
200
GTEPQDEAKQ
PAEEEQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Biological Process |
GO:0051168 |
nuclear export |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.