Search Results
Overview
| Uniprot ID | A0A287BAB0 |
|---|---|
| Protein Name | Squalene synthase |
| Gene Name | FDFT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 45 | SSLKTCYKYLNQTSR |
Function
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway
Protein Sequence
10
MEFVKCLGHP
20
EEFYNLLRFQ
30
MGGRRKVIPK
40
MNQDSLSSSL
50
KTCYKYLNQT
60
SRSFAAVIQA
70
LDGEMRHAVC
80
IFYLVLRALD
90
TLEDDMTISI
100
EKKIPLLHNF
110
HLHLYESDWR
120
FTESKEKDRQ
130
VLEDFPTYCH
140
YVAGLVGIGL
150
SRLFSASELE
160
DPLVGEDTER
170
ANSMGLFLQK
180
TNIIRDYLED
190
QQEGREFWPQ
200
EVWSKYVKKL
210
GDFAKPENVD
220
LAVQCLNELV
230
TSTLHHIPDV
240
ITYLSRLRNQ
250
SIFNFCAIPQ
260
VMAIATLAAC
270
YNNQQVFKGV
280
VKIRKGQAVT
290
LMMDATNMPA
300
VKAIIHQYME
310
EIYHRIPDSD
320
PYSAKTRQII
330
STIRTQNLPN
340
CQLISRSHYS
350
PIYLSFVMLL
360
AALSWQYLST
370
LSQVTEDYVQ
TGEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0055056 | D-glucose transmembrane transporter activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051996 | squalene synthase [NAD(P)H] activity |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0045338 | farnesyl diphosphate metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.