Search Results
Overview
| Uniprot ID | A0A287BB19 |
|---|---|
| Protein Name | Ran-binding protein 3 |
| Gene Name | RANBP3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 267 | SEEENCEKKEQVAQQ |
| 268 | EEENCEKKEQVAQQA |
Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export
Protein Sequence
10
MADLANEEKP
20
AIAPPVFVFQ
30
KDKGQKSSAE
40
QKDLSDSGEE
50
PRGEAEAPHH
60
GTGHPESAGE
70
HALELPAPAS
80
ASASTPEAQL
90
LPFPRELAGR
100
SAGGSSPEGG
110
EDSDREDGNY
120
CPPVKRERTS
130
SLTQFPPSQS
140
VSKNNVFMPS
150
TFCEPSAGNS
160
DSEPEEKSSG
170
FRLKPPTLIH
180
GQAPSAGLPS
190
QKPKEQQRSV
200
LRPAVLQAPQ
210
PKALSQTVPS
220
TGTNGVSVPA
230
DCTGAVTLAS
240
PDNPARRSPS
250
DEVPALEEKE
260
SQKNESSNTS
270
EEENCEKKEQ
280
VAQQAFVFGQ
290
NLRDRVKLIN
300
ENTEVADMEN
310
AGHPSSETPT
320
ATNYFLQYIS
330
SSLENSTNSA
340
DAASSKFIFG
350
QNMSERVLSP
360
PKLNEVSSDA
370
NRETIAAESG
380
SESSSQEATP
390
EKANNVAESL
400
AESAAAYTKA
410
TARKCLLEKV
420
EVITGEEAES
430
NVLQIQCKLF
440
VFDKTSQSWV
450
ERGRGLLRLN
460
DMASTDDGTL
470
QSRLVMRTQG
480
SLRLILNTKL
490
WAQMQIDKAS
500
EKSIRITAMD
510
TEDQGVKVFL
520
ISASSKDTGQ
530
LYAALHHRIL
540
ALRSRVEQEQ
550
EAKTPAPEPG
560
AAPSNEDDSD
570
DDDVLAPSGA
580
TGSGAGDEGD
GQTAGST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.