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Overview

Uniprot IDA0A287BBA7
Protein NameSuperkiller complex protein 3
Gene NameSKIC3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
120 QKWCDVCKKLVDLYY
1289 DDKLALVKNTQPKRI
433 ALIHFTKKDYLQAEK

Function

Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C)

Protein Sequence

10 MSSKEVKTAL 20 KSARDAIRNK 30 EYKEALKHCK 40 TVLKQEKNNY 50 NAWVFIGVAA 60 AELEQPDQAQ 70 GAYKKAAELE 80 PDQLLAWQGL 90 ASLYEKCNHV 100 NAKDDLPGVY 110 QKLLDLYESV 120 DKQKWCDVCK 130 KLVDLYYQEK 140 KHVEVARTWH 150 KLIKTRQEEG 160 ADNQELHQLW 170 RKLTQLLAES 180 TEDQNNETQQ 190 LLLTAFENAL 200 GLSDKIPSED 210 HQVLYRHFIQ 220 CLSKFPHETS 230 RLKKACEGMI 240 NIYPTVQYPL 250 EVLCLHLIES 260 GSLTDEGAQY 270 CCRLVEMDSK 280 SGPGLIGLGI 290 KALQDKKYED 300 AVRNLTEGLK 310 ESPLCTTGWY 320 HLAGAQVKMH 330 KPKEAILSCN 340 QALKNIDNLG 350 VSGSLHQKNL 360 CLHLKAEALI 370 KLSDFESSEE 380 AIRTLDQVSD 390 ANNVPGLLVL 400 KGLAHLNKGS 410 LDEASKIMED 420 LLSSYPDLAE 430 AHALEALIHF 440 TKKDYLQAEK 450 CFQRALEKDA 460 EVAEYHYQLG 470 LTYWSMGEET 480 RKDKTKALTH 490 FLKAAKLDTY 500 MGKVFCYLGH 510 YYRDVVGDKN 520 RARGCYRKAF 530 ELDDTDAESG 540 AAAVDLSVEL 550 EEMETALAIL 560 TTVTQKASAG 570 TAKWAWLRRG 580 LYYLKAGQHS 590 QAVADLQAAL 600 RADPKDFNCW 610 ESLGEAYLSR 620 GGYTTALKSF 630 TKASELNPES 640 TYSVFKVAAI 650 QQILGKYKEA 660 VAQYQLIIKK 670 KEDYVPALKG 680 LGECHLMMAR 690 AALVDYLDGK 700 AVDYIEKALE 710 YFTRALQHRA 720 DVSCLWKLVG 730 DACTSLYAVS 740 PSKVNVSVLG 750 ILLGQKEGKQ 760 ILKKNEILHL 770 GGRCYGRALK 780 LMSTSNTWCD 790 LGINYYRRAQ 800 HLVETGSNSN 810 DLQELLEKSL 820 HCLKKAVRLD 830 SSNHLYWNAL 840 GVVSCYSGIG 850 NYALAQHCFI 860 KSIQSEQINA 870 VAWTNLGVLY 880 LANEKIEQAH 890 EAFKMAQSLD 900 PSYLLCWIGQ 910 ALIAETVGSY 920 DTMDLFRHTT 930 ELSMHTEGAI 940 GYAYWVCTTL 950 QDKSNRDTEL 960 YQYNILQMNA 970 VPAAQVVLSK 980 YIERIQNYAP 990 AFTMLGYLNE 1000 HLQLKKEAAD 1010 AYQRAILLLQ 1020 TAEDPDTYYV 1030 TMRDYGRLLC 1040 SIGEYDKAIQ 1050 AFKSTPLEEL 1060 EDIVGFALAL 1070 FMKGLYKESS 1080 KAYERALSVV 1090 ESEQDKAHIL 1100 TALAITEYKQ 1110 RKMDVAKTLL 1120 FKCSILKEPT 1130 TESLQTLCAL 1140 GLAMQDATLS 1150 KAALNELLKH 1160 VKQKDSDYQR 1170 CLLTSAIYAL 1180 QGRSVAVQRQ 1190 ASKAVHSNPA 1200 DPALWSFLSR 1210 VVAQYTQRSA 1220 KGGAVAGNVA 1230 HILDSNHGKK 1240 ALLYTAVNQL 1250 AMGSNSAEDE 1260 KNTALKTIQK 1270 AALLSPGDPA 1280 VWAGLMAACH 1290 ADDKLALVKN 1300 TQPKRIDLYL 1310 ALLSAVSASI 1320 KDKEFLENYK 1330 QSLEKWSLSQ 1340 AVTSLIDTGR 1350 VSENLKSNPD 1360 QPAVILLLRQ 1370 VQCKALLESQ 1380 KPLPDAVLEE 1390 LQKTVVSNST 1400 SVPAWQWLAH 1410 IYQSQGMMGA 1420 AEMCYRKSLQ 1430 VASQQGSWSG 1440 KLSSLLRLAL 1450 LALEVCMANI 1460 STDHWPSLVQ 1470 EATAEALKLC 1480 FCPLAVLLQA 1490 LLQFNRKMGA 1500 RETRRLLERV 1510 VYQPGYPKSI 1520 VSTARWYLLR 1530 HLHAKNDYEL 1540 IDVLVNNAQT 1550 HGDTRALELN QKLSSQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0055087 Ski complex
Biological Process GO:0000956 nuclear-transcribed mRNA catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.