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Overview

Uniprot IDA0A287BBE5
Protein NameUbiquitin carboxyl-terminal hydrolase
Gene NameUSP30
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
337 PRGEPCRKAGPALEV

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes

Protein Sequence

10 MLSSRAEAAM 20 TAADRAIQRF 30 LRTGAAVRYK 40 VMKNWGVIGG 50 IAAALAAGIY 60 VIWGPITERK 70 KRRKGLVPGL 80 VNLGNTCFMN 90 SLLQGLSACP 100 TFIKWLEEFT 110 TQYTRDQKEP 120 PQHQYLSLTL 130 LHLLKDAHEL 140 FHVITSSLED 150 ERDHQPRVTH 160 LFDVHSLEQQ 170 PEITPRQITC 180 RTRGSPHPMF 190 NHWKSQHPFH 200 GRLTSNMVCK 210 HCEHQSPVRF 220 DTFDSLSLSI 230 PAATWGHPLT 240 LDHCLHHFIS 250 SESVRDVVCD 260 NCTKIEAKGT 270 LNGEKVEHQR 280 TTFVKQLKLG 290 KLPQCLCIHL 300 QRLSWSSHGT 310 PLKRHEHVQF 320 SEFLMMDIYK 330 YHLLGHKPGP 340 RGEPCRKAGP 350 ALEVQDGPAA 360 PKSVRSQPGG 370 PKTQMLMNGA 380 CSPPFLPTLP 390 APVPFPLPAV 400 PDHSSSAYLF 410 QLMAVVVHHG 420 DMHSGHFVTY 430 RRSPPSAKNP 440 LSTSNQWLWI 450 SDDTVRKASL 460 QEVLSSSAYL 470 LFYERVLSKM 480 QHQNREYKSE E

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0004197 cysteine-type endopeptidase activity
Biological Process GO:0000422 autophagy of mitochondrion
Biological Process GO:0008053 mitochondrial fusion
Biological Process GO:0035871 protein K11-linked deubiquitination
Biological Process GO:0044313 protein K6-linked deubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0031647 regulation of protein stability

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.