Search Results

Overview

Uniprot ID	A0A287BBF3
Protein Name	3-hydroxyisobutyryl-CoA hydrolase
Gene Name	HIBCH
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
108	RVISENTKTNPKMVQ
92	IMKGAGEKAFCAGGD

Function

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA

Protein Sequence

10 MGLWKVWSFT 20 SRFNSSKRTN 30 TILQHLTMSK 40 HTDAAAEVLL 50 ERKGCAGVIT 60 LNRPKFLNAL 70 NLSMIQQIYP 80 QLKKWEQDPE 90 TFLIIMKGAG 100 EKAFCAGGDI 110 RVISENTKTN 120 PKMVQDFFRE 130 EYMLNNAIDS 140 CLKPYIALIH 150 GITMGGGVGL 160 SVHGQFRVAT 170 EKSLFAMPET 180 AIGLFPDVGG 190 GYFLPRLQGK 200 LGYFLALTGF 210 RLKGRDVYTA 220 GIATHFVDSE 230 KLGMLEDDLL 240 ALNSPSKENI 250 ADVLETYHTK 260 SKIDQDKSFI 270 LEEHMDKINS 280 WFSANTVEEI 290 IENLQQDGSS 300 FALEQLKVIN 310 KMSPTSLKIT 320 LRQLMEGSSK 330 TLPEVLTMEY 340 RLSQACIAWS 350 LILGKNCPDV 360 LSFKWIRSSR 370 SKMRESRYEP 380 RRSNILREAM TFMKALGQF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity
Biological Process	GO:0006574	L-valine catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.