Search Results

Overview

Uniprot IDA0A287BBG3
Protein NameCLIP-associating protein 1
Gene NameCLASP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1336 TIRALALKVLREILR
1487 KLLNLYIKRAQTGSG
240 ILSVCKDKSFDDEES

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRSMEYFS 20 AQVQQKDVGG 30 RLQVGQELLL 40 YLGVPGAIPD 50 LEENLGCLGK 60 TVDALTGWVG 70 SSNYRVSLMG 80 LEILSAFVDR 90 LSTRFKSYVA 100 MVIVALIDRL 110 GDAKDKVRDK 120 TQALILKLMD 130 QVAPPMYIWE 140 QLASGFKHKN 150 SQSREGVCLC 160 LIETLNVFGA 170 QPLVLSKLVP 180 HLCILFGDYN 190 SQVRDAATLA 200 IVEIYRHVGD 210 KVRMDLYKKG 220 IPPARLETIL 230 AKFDEVQNSG 240 GMILSVCKDK 250 SFDDEESVDG 260 NRPSSAASAF 270 KVPAPKTSGN 280 PVNSARKPGS 290 AGGPKVGGAS 300 KEGGAGAVDE 310 DDFIKAFTDV 320 PSIQIYSSRE 330 LEETLNKIRE 340 ILSDDKHDWD 350 QRANALKKIR 360 SLLVAGAAQY 370 DCFFQHLRLL 380 DGALKLSAKD 390 LRSQVVREAC 400 ITVAHLSTVL 410 GNKFDHGAEA 420 IVPTLFNLVP 430 NSAKVMATSG 440 CAAIRFIIRH 450 THVPRLIPLI 460 TSNCTSKSVP 470 VRRRSFEFLD 480 LLLQEWQTHS 490 LERHAAVLVE 500 TIKKGIHDAD 510 AEARVEARKT 520 YMGLRNHFPG 530 EAETLYNSLE 540 PSYQKSLQTY 550 LKSSGSVASL 560 PQSDRSSSSS 570 QESLNRPFSS 580 KWSTANPSTV 590 AGRVSTGSSK 600 ANSLPGSLQR 610 SRSDIDVNAA 620 AGAKAHHAAG 630 QSVRSGRLGA 640 GALNPGSYAS 650 LEDTSDKMDG 660 TASDDGRVRA 670 KLSAPLAGMG 680 SAKTDTRGRS 690 RTKMVSQSQP 700 GSRSGSPGRV 710 LTTTALSTVS 720 SGVQRVLVNS 730 ASAQKRSKIP 740 RSQGCSREAS 750 PSRLSVARSS 760 RIPRPSVSQG 770 CSREASRESS 780 RDTSPVRSFQ 790 PLGPGYGISQ 800 SSRLSSSVSA 810 MRVLNTGSDV 820 EEAVADALKK 830 PARRRYESYG 840 MHSDDDANSD 850 ASSACSERSY 860 SSRNGSIPTY 870 MRQTEDVAEV 880 LNRCASSNWS 890 ERKEGLLGLQ 900 NLLKNQRTLS 910 RVELKRLCEI 920 FTRMFADPHG 930 KRVFSMFLET 940 LVDFIQVHKD 950 DLQDWLFVLL 960 TQLLKKMGAD 970 LLGSVQAKVQ 980 KALDVTRESF 990 PNDLQFNILM 1000 RFTVDQTQTP 1010 SLKVKVAILK 1020 YIETLAKQMD 1030 PGDFINSSET 1040 RLAVSRVITW 1050 TTEPKSSDVR 1060 KAAQSVLISL 1070 FELNTPEFTM 1080 LLGALPKTFQ 1090 DGATKLLHNH 1100 LRNTGNGTQG 1110 SMGSPLTRPT 1120 PRSPANWSSP 1130 LTSPTNTSQN 1140 TLSPSAFDYD 1150 TENMNSEDIY 1160 SSLRGVTEAI 1170 QNFSFRSQED 1180 MNEPLKRESK 1190 KDDVDSMCGG 1200 PGMSDPRAGG 1210 DATDSSQTAL 1220 DNKASLLHSM 1230 PAHSSPRSRD 1240 YNPYNYSDSI 1250 SLFNKSALKE 1260 AMFDDDADQF 1270 PDDLSLDHSD 1280 LVAELLKELS 1290 NHNERVEERK 1300 IALYELMKLT 1310 QEESFSVWDE 1320 HFKTILLLLL 1330 ETLGDKEPTI 1340 RALALKVLRE 1350 ILRHQPARFK 1360 NYAELTVMKT 1370 LEAHKDPHKE 1380 VVRSAEEAAS 1390 VLATSISPEQ 1400 CIKVLCPIIQ 1410 TADYPINLAA 1420 IKMQTKVIER 1430 VSKETLNLLL 1440 PEIMPGLIQG 1450 YDNSESSVRK 1460 ACVFCLVAVH 1470 AVIGDELKPH 1480 LSQLTGSKMK 1490 LLNLYIKRAQ 1500 TGSGGGDPTT DVSGQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005819 spindle
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0051301 cell division
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0007026 negative regulation of microtubule depolymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.