Overview
| Uniprot ID | A0A287BBX9 |
|---|
| Protein Name | Craniofacial development protein 1 |
|---|
| Gene Name | CFDP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 187 |
KEVDATSKEAKSFFK |
| 54 |
KTKGKKRKAQSIPAR |
Function
Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development
Protein Sequence
10
MEEFDSEDFS
20
TSEEDEDYVP
30
SGGEYSEDDV
40
SELVKEDEVD
50
GDEQTQKTKG
60
KKRKAQSIPA
70
RKRKQGGLSF
80
EEEEEENANE
90
ESGGSSSEEE
100
DSAAEQEKGI
110
GSEDARKKKE
120
DELWASFLND
130
VGPKSKVPPS
140
THVKKGEETE
150
ETSSSKLLVK
160
AEDLEKPKET
170
EKVKITKVFD
180
FAGEEVRVTK
190
EVDATSKEAK
200
SFFKQNEKEK
210
PQANVPSALP
220
SLAAGSGLKR
230
SGGMSSLLGK
240
IGAKKQKMST
250
LEKSKLDWES
260
FKEEEGIGEE
270
LAIHNRGKEG
280
YIERKAFLDR
290
VDHRQFEIER
DLRLSKMKP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0000812 |
Swr1 complex |
| Biological Process |
GO:0006338 |
chromatin remodeling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.