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Overview

Uniprot IDA0A287BCJ5
Protein NameExtended synaptotagmin-2
Gene NameESYT2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
168 VYTENVDKRQIILDL
291 QLRFPVPKGVLRIHF
312 QGKDTYLKGLVKGKS
765 RLYLLPDKRRSGRRK

Function

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS)

Protein Sequence

10 MSGPRAPGPE 20 AGAAGAEPPG 30 AALSVDVTGL 40 LAQLARSFAL 50 LLPVYALGYL 60 GLSFSWVLLA 70 LGLLVWCRRS 80 RGLKATRLCR 90 ALALLEDEER 100 AVRLGVRACD 110 LPAWVHFPDT 120 ERAEWLNKFI 130 EKLFRETIEP 140 AVRGAHPHLS 150 TFSFTRVDVG 160 QQPLRINGVK 170 VYTENVDKRQ 180 IILDLQISFV 190 GNCEIDLEIK 200 RYFCRAGVQS 210 IQIHGTMRVI 220 LEPLIGDMPL 230 VGALSIFFLR 240 KPLLEINWTG 250 LTNLLDIPGL 260 NGLSDTIILD 270 IISNYLVLPN 280 RVTVPLVSEV 290 QIAQLRFPVP 300 KGVLRIHFIE 310 AQDLQGKDTY 320 LKGLVKGKSD 330 PYGVLRVGNQ 340 IFQSKVIKES 350 LSPKWNEVYE 360 ALVYEHPGQE 370 LEIELFDEDP 380 DKDDFLGSLM 390 IDLIEVEKER 400 LLDEWFALDE 410 VPKGKLHLKL 420 EWLTLVPNAV 430 NLEKVLTDIR 440 ADKDQATDGL 450 SSSLLILYLD 460 SARNLPSNPL 470 EFNADVLKKA 480 AIQKALKSGK 490 KMNSNPSPLV 500 QMSVGHKAQE 510 SKIRYKTNEP 520 VWEENFTFFI 530 HNPKRQELEV 540 EVRDEQHQCS 550 LGNLRIPLSQ 560 LLASEDMTMN 570 QRFQLSNSGP 580 NSSLKMKLAL 590 RVLHLEKQER 600 SPDHQHSAQV 610 KRPSVSKEGR 620 KIPVRPQMSA 630 SPGTGDSSTA 640 PSSPVVGGGD 650 KPGVEERAPP 660 AEASPQGPQD 670 LGRSSSSLQA 680 SGTGSPSHIS 690 VKEPTPSIAS 700 DISLPIATQE 710 LRQRLRQLEN 720 GTTLGQSPLG 730 QIQLTIRHSS 740 QRNKLVVVVH 750 SCRNLIAFSE 760 DGSDPYVRLY 770 LLPDKRRSGR 780 RKTHVSKKTL 790 NPVFDQSFDF 800 SVSLPEAQRR 810 TLDVAVKNSG 820 GFLSKDKGLL 830 GKVLVGLASE 840 ELAKGWTQWY 850 DLTEDGTRPH VVT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0061817 endoplasmic reticulum-plasma membrane tethering
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.