Search Results
Overview
| Uniprot ID | A0A287BD48 |
|---|---|
| Protein Name | Zinc finger CCCH domain-containing protein 14 |
| Gene Name | ZC3H14 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | VSSTRPEKRDSRVST |
| 307 | SSVVKVKKFNHDGEE |
| 352 | PPSKQANKNLILKAI |
| 690 | RYFPACKKMECPFYH |
| 728 | VPPRHALKWIRPQTS |
Function
RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells
Protein Sequence
10
MEIGTEISRK
20
IRSAIKGKLQ
30
ELGAYVDEEL
40
PDYIMVMVAN
50
KKSQDQMTED
60
LSLFLGNNTI
70
RFTVWLHGVL
80
DKLRSVTTDP
90
SSFKSSDTNI
100
FDSNVPSNKS
110
SFSRGDERRH
120
EAAVPPLAVS
130
STRPEKRDSR
140
VSTSSQEQKA
150
TNVRQTYDDG
160
AATRLMSTVK
170
PLREPAPSED
180
VIDIKPEPDD
190
LIDEDLNFVQ
200
ENPLSQKKPT
210
VTLTYGSSRP
220
SIEIYRPPAS
230
RNADSGAHLN
240
RLQFQQQQNS
250
IHAAKQVDIQ
260
SSRVYETGRL
270
CEPEVLNSLE
280
ETYSPFFRNN
290
SEKMSIEEEN
300
FRKRKLPVVS
310
SVVKVKKFNH
320
DGEEEEEEDD
330
CGSRTGSISS
340
SVSVPAKPER
350
RPSLPPSKQA
360
NKNLILKAIS
370
EAQESVTKTT
380
NYSTVSQKQT
390
LPVAPRTRTS
400
QEELLAEMVQ
410
GQSKAPRISS
420
PIKEEETKGD
430
NIDKSQGTQQ
440
RQLLSRLQID
450
PVMAETLQIS
460
QDYYDMESMV
470
HADTRSFILK
480
KPKLSEEIVV
490
APNQESGMKT
500
ADTLRVLSGH
510
LMQTRDLVQP
520
DKPASPKFIV
530
TLDGVPSPPG
540
YMSDQEEDMC
550
FEGMRPAHHT
560
AASHEGLAGL
570
LHPQQLHLLS
580
RQLEDPDGSF
590
SNAEMSELSV
600
AQKPEKLLER
610
CKYWPACKNG
620
DECAYHHPIS
630
PCKAFPNCKF
640
AEKCLFVHPN
650
CKYDAKCTKP
660
DCPFTHMSRR
670
IPVLPPKPAV
680
TTPAPPSSSQ
690
LCRYFPACKK
700
MECPFYHPKH
710
CRFNTQCTRP
720
DCTFYHPTIT
730
VPPRHALKWI
RPQTSE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0008143 | poly(A) binding |
| Molecular Function | GO:0036002 | pre-mRNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0048255 | mRNA stabilization |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0160091 | spliceosome-depend formation of circular RNA |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.