Search Results

Overview

Uniprot IDA0A287BD60
Protein NameTripeptidyl-peptidase 2
Gene NameTPP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1172 RGLKFATKLVEEKPT
1177 ATKLVEEKPTKENWK
1180 LVEEKPTKENWKNCI

Function

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis

Protein Sequence

10 MATAATEEPF 20 PFHGLLPKKE 30 TGAASFLCRY 40 PEYDGRGVLI 50 AVLDTGVDPG 60 APGMQVTTDG 70 KPKIIDIIDT 80 TGSGDVNTAT 90 VAEPKDGELI 100 GLSGRVLKKE 110 RKEKIWDPVH 120 RVALAEACRK 130 QEEFDVANSC 140 PSQANKLIKE 150 ELQSQVELLN 160 SFEKKYSDPG 170 PVYDCLVWHD 180 GETWRACIDS 190 NEDGDLSKST 200 VLRNYKEAQE 210 YGSFGTAEML 220 NYSVNIYDEG 230 NLLSIVTSGG 240 AHGTHVASIA 250 AGHFPEEPER 260 NGVAPGAQIL 270 SIKIGDTRLS 280 TMETGTGLIR 290 AMIEVINHKC 300 DLVNYSYGEA 310 THWPNSGRIC 320 EVISEAVWKH 330 NIIYVSSAGN 340 NGPCLSTVGC 350 PGGTTSSVIG 360 VGAYVSPDMM 370 VAEYSLREKL 380 PANQYTWSSR 390 GPSADGALGV 400 SISAPGGAIA 410 SVPNWTLRGT 420 QLMNGTSMSS 430 PNACGGIALI 440 LSGLKANNAD 450 YTVHSVRRAL 460 ENTAVKADNI 470 EVFAQGHGII 480 QVDKAYDYLV 490 QNTSFANKLG 500 FTVTVGNNRG 510 IYLRDPIQVA 520 APSDHGVGIE 530 PVFPENTENS 540 EKISLQLHLA 550 LTSNSSWVQC 560 PSHLELMNQC 570 RHINIRVDPR 580 GLREGLHYTE 590 VCGYDTASPN 600 AGPLFRVPIT 610 AVIAAKVNES 620 SHYDLAFTDV 630 HFKPGQIRRH 640 FIEVPEGATW 650 AEVTVCSCSS 660 EVSAKFVLHA 670 VQLVKQRAYR 680 SHEFYKFCSL 690 PEKGTLTEAF 700 PVLGGKAIEF 710 CIARWWASLS 720 DVNIDYTISF 730 HGIVCTAPQL 740 NIHASEGINR 750 FDVQSSLKYE 760 DLAPCITLKS 770 WVQTLRPLSA 780 KTKPLGSRDV 790 LPNNRQLYEM 800 ILTYNFHQPK 810 SGEVTPSCPL 820 LCELLYESEF 830 DSQLWIIFDQ 840 NKRQMGSGDA 850 YPHQYSLKLE 860 KGDYTIRLQI 870 RHEQISDLER 880 LKDLPFIVSH 890 RLSNTLSLDI 900 HENHSLALLG 910 KKKSSNLTLP 920 PKYNQPFFVT 930 SLPDDKIPKG 940 AGPGCYLSGS 950 LTLSKTELGK 960 KADVIPVHYY 970 LISPPTKTKN 980 GSKDKDKDSE 990 KEKDLKEEFT 1000 EALRDLKIQW 1010 MTKLDSSDIY 1020 NELKETYPNY 1030 LPLYVARLHQ 1040 LDAEKERMKR 1050 LNEIVEAANA 1060 VISHIDQTAL 1070 AVYIAMKTDP 1080 RPDAAIIKND 1090 MDKQKSTLVD 1100 ALCRKGCALA 1110 DHLLQAQEQE 1120 GAVSSDAEGR 1130 EEEGEGTLDS 1140 LTETFWETTK 1150 WTDLFDSKVL 1160 TFAYKHALVN 1170 KMYGRGLKFA 1180 TKLVEEKPTK 1190 ENWKNCIQLM 1200 KLLGWTHCAS 1210 FTENWLPIMY PPDYCVF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004177 aminopeptidase activity
Molecular Function GO:0004252 serine-type endopeptidase activity
Molecular Function GO:0008240 tripeptidyl-peptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.