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Overview

Uniprot ID	A0A287BDJ5
Protein Name	Drebrin
Gene Name	DBN1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
271	EEETQMKKSESEVEE
295	DNPREFFKQQERVAS

Function

Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus

Protein Sequence

10 MAGVSFSGHR 20 LELLAAYEEV 30 IREESSADWA 40 LYTYEDGSDD 50 LKLAASGDGG 60 LQELSGHFEN 70 QKVMYGFCSV 80 KDSQAALPKY 90 VLINWVGEDV 100 PDARKCACAS 110 HVAKVAEFFQ 120 GVDVIVNASS 130 VEDIDAGAIG 140 QRLSNGLARL 150 SSPVLHRLRL 160 REDENAEPVG 170 TTYQKTDAAV 180 EMKRINREQF 190 WEQAKKEEEL 200 RKEEERKKAL 210 DERLRFEQER 220 MEQERQEQEE 230 RERRYREREQ 240 QIEEHRRKQQ 250 TLEAEEAKRR 260 LQEQSIFGDQ 270 RDEEEETQMK 280 KSESEVEEAA 290 AIIAQRPDNP 300 REFFKQQERV 310 ASASAGSCDV 320 PSPFNHRPGS 330 HLDSHRRMAP 340 TPIPARSPSD 350 SSTASTPVAE 360 QIERALDEVT 370 SSQPPPLPPP 380 PPPAQETQEP 390 SPGLDSEETS 400 KEAREAAPQA 410 WAGPVEEPPQ 420 APEPPQGRGS 430 PPEDLMFMAS 440 TEQAVLAAPL 450 EPAMAGASAA 460 DTLVADAIEA 470 DTAAADTAVA 480 NTVTPAAASL 490 IDLWPGNGEE 500 ASAPQAEPRA 510 PTPPSGAEVP 520 LAEVPLLDEV 530 AQEPLPPAGE 540 GSANLLNFDE 550 LPEPPATFCD 560 QEEEVEGVSL 570 AVPQAPTLPS 580 ALEELDLEPE 590 PEPHLLTNGE 600 TTQKEGTQAS 610 EGYFSQSQEE 620 EFAQSEELCA 630 KAPPPVFYNK 640 PPEIDITCWD 650 ADPVPEEEEG FEGGD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0030426	growth cone
Molecular Function	GO:0003779	actin binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007399	nervous system development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.