Search Results
Overview
| Uniprot ID | A0A287BEZ7 |
|---|---|
| Protein Name | Sphingosine-1-phosphate lyase 1 |
| Gene Name | SGPL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 410 | SVVLYSDKKYRNYQF |
| 466 | EATKQIIKTTRFLKA |
| 472 | IKTTRFLKAELENIK |
Function
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance
Protein Sequence
10
MGRSAEAGSR
20
LRRGEAPKGG
30
LEEEDAEYGP
40
SHVEKYISSF
50
ITRCEGKNAL
60
LAFEPYFEIL
70
EVYSTKAKNY
80
VNGHCTKYEP
90
WQLIAWSVVW
100
TLLIVWVYKF
110
VFQPESLWSR
120
FKKRCVKLIR
130
KMPVIGRKIQ
140
DKLNKTKDDI
150
SKNMSFLKVD
160
KEYVKALPSQ
170
GLSPAAVLEK
180
LKEYSSLDVS
190
WQEGKASGAV
200
YSGEKELTEL
210
LVKAYGDFAW
220
SNPLHPDIFP
230
GLRKIEAEIV
240
RMACSLFNGG
250
PDSCGCVTSG
260
GTESILMACK
270
AYRELAFENG
280
IKTPEIVAPQ
290
SAHAAFDKAA
300
NYFGMKIIRV
310
PLNKMMEVDI
320
RAMRRAISRN
330
TAMLVCSTPQ
340
YPHGVIDPVP
350
EVAKLAVKYK
360
IPLHVDACLG
370
GFLIVFMEKA
380
GYPLEQPFDF
390
RVKGVTSISA
400
DTHKYGYAPK
410
GSSVVLYSDK
420
KYRNYQFFVA
430
TDWQGGIYAS
440
PTMAGSRPGG
450
ISAACWAALM
460
YFGENGYVEA
470
TKQIIKTTRF
480
LKAELENIKG
490
IFVFGNPQLS
500
VIALGSRDFD
510
IFRLFNLMTA
520
KGWNLNQLQF
530
PPSIHFCITL
540
VHTRKRVAIQ
550
FLKDIRESVT
560
QIMKNPKAKT
570
TGMGAIYGMA
580
QATIDRNLVA
590
ELSSFFLDSL
600
FSTDAVPQGS
QMNGSPKPR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0008117 | sphinganine-1-phosphate aldolase activity |
| Biological Process | GO:0097190 | apoptotic signaling pathway |
| Biological Process | GO:0006672 | ceramide metabolic process |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0030149 | sphingolipid catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.