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Overview

Uniprot IDA0A287BF68
Protein NameNuclear pore complex protein Nup153
Gene NameNUP153
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1052 SVAPFTCKTPEAKKE
662 QNKVADNKCVACQAT
678 LPPRDTAKQLGTGTP
734 CVACETPKPGTGVKR

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Protein Sequence

10 MGERKRCGWR 20 PLRLIFSSLP 30 RFSGILSRVT 40 ESVKNIVPGW 50 LQRYFNKNED 60 VCSCSTDTRE 70 VPQWPENRED 80 DHTMYADEEG 90 ASVHDGRITP 100 EPTVSNTEEP 110 STTSTASNYP 120 DVLTRPSLHR 130 SHLNFSMLES 140 PALHCQPSTS 150 SAFPIGSSGF 160 SLVKEIKDST 170 SQHDDDNIST 180 TSGFSSRASD 190 KDIAVSKNTS 200 VPPLWSPEAE 210 RSHSLSQHTA 220 TSSKKPAFNL 230 SAFGTLSPSL 240 GNSSILKTSQ 250 LGDSPFYPGK 260 TMYGGAAAAV 270 RQPKLQNTPY 280 QAPVRRQMKA 290 KQLNAQSYGV 300 TSSTARRILQ 310 SLEKMSSPLA 320 DAKRIPSVFS 330 SLNSSLDRSG 340 IDNTTDLQAK 350 RRKVDSQNPP 360 VQGLMTPKPV 370 SIAANRTVYF 380 KPSLTPSGEL 390 RKTNQRVDKK 400 HSTGYEKNMS 410 PGQNKERESG 420 FSYPNFSMSA 430 ANGLSSGVGS 440 GGGKMRRERT 450 RFVASKPQDE 460 EEMEVPVLPK 470 ISLPITSSSL 480 PTFNFSSSVI 490 TTSSPSPISP 500 SQSLTNKVQM 510 TSPNSTGSPL 520 FRFSSPIVKS 530 TEADVLPPSS 540 IGFTFSVPVA 550 KTELSGSSTI 560 SEPIMSSSAE 570 DITAVNNSTS 580 CKKADEDGEG 590 LFRPAKTLKE 600 GSVLDVLKNP 610 GFTSPKADSP 620 AAQPTTTSPI 630 VYTRPAISSS 640 SSSGIGFGES 650 LKAGPSWQCD 660 TCLLQNKVAD 670 NKCVACQATK 680 LPPRDTAKQL 690 GTGTPSKSGK 700 PTLSSPGTGF 710 GDKFKPAVGT 720 WDCDTCLVQN 730 KPEAIKCVAC 740 ETPKPGTGVK 750 RVFTLPVASE 760 SAVTMAASSS 770 SCTVTTGALG 780 FTDKFKRPMG 790 SWECPVCCVS 800 NNAEDNKCVS 810 CMSEKPGSSV 820 PASSSSTVPV 830 SVLSGGSLGL 840 DKFKKPEGNW 850 NCDVCLVENK 860 ADSTKCIACE 870 SAKPGTKSEF 880 KGFGTSSSSL 890 NPATSSFKFG 900 IPSSSSAPSQ 910 TLTNTGNFKF 920 GDQGGFKIGV 930 SSDLGSVNPM 940 SEEGFKFPKP 950 IGDFKFGVSS 960 DSKPEEVKKD 970 SKNDNNFKFG 980 LSSGLSNPAP 990 LAPFQFGVSN 1000 LGQQEKKEEV 1010 PESSSAGFSF 1020 CSGVINPPPL 1030 AADTKVTSES 1040 KNSFSFGTTD 1050 TKSVSVAPFT 1060 CKTPEAKKEE 1070 TPVTKGGFTF 1080 GSMDSAPLPS 1090 ASFVLGRTEE 1100 KQQEPVTSTS 1110 LVFGKKVDTE 1120 EPKCQPVFSF 1130 GNSEQTKDEG 1140 SSKSTFSFST 1150 AKPSEKESEQ 1160 PAKATFAFGA 1170 QTSTTADQGA 1180 AKPVFSFLNN 1190 NSSNSSTPAT 1200 SAGGGIFGSS 1210 TTSSSAPVAA 1220 FVFGQASNPV 1230 SSSAFGNSAE 1240 SSTSQSLLFS 1250 QESKPATTSS 1260 TGTAVTPFVF 1270 GPGPSSNNTA 1280 TSGFTFGATT 1290 TSSSAGSSFV 1300 FGTGPSAPSA 1310 SPAFGANQTP 1320 TFGQSQGASQ 1330 PNPPGFGSIA 1340 SSAALFSAGS 1350 QPAPPTFGTV 1360 SSSSQPPVFG 1370 QQPSQSAFGS 1380 GTAPNSSSVF 1390 QFGSSTTNFN 1400 FTNNNPSGVF 1410 TFGANPSIPA 1420 ASAQPSGSGG 1430 FPFNQSPGAF 1440 TVGSNGKNIF 1450 SSSGTSLSGR 1460 KIKTAVRRRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0044615 nuclear pore nuclear basket
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051028 mRNA transport
Biological Process GO:0015031 protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.