Search Results
Overview
| Uniprot ID | A0A287BFB8 |
|---|---|
| Protein Name | PKC-interacting cousin of thioredoxin |
| Gene Name | GLRX3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | AHAPELTKKVQRHAS |
| 242 | IKELEASKELDTICP |
| 250 | ELDTICPKAPKLEER |
| 253 | TICPKAPKLEERLKV |
| 259 | PKLEERLKVLTNKAS |
Function
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity
Protein Sequence
10
MAAGAAEAAA
20
AVVEVGSAGQ
30
FEELLRLRAK
40
SLLVVHFWAP
50
WAPQCAQMND
60
VMAELAKEHP
70
QVSFVKTKTP
80
KSYFLKPEFV
90
SSEDVLLEAE
100
AVPEVSEKYG
110
ISSVPTFLFF
120
KNSQSIDRLD
130
GAHAPELTKK
140
VQRHASSSSF
150
PSGGSEHLKE
160
DLSLRLKKLT
170
HAAPCMLFMK
180
GTPQEPRCGF
190
SKQMVEILNK
200
HNIQFSSFDI
210
FSDEEVRQGL
220
KTYSNWPTYP
230
QLYVSGELIG
240
GLDIIKELEA
250
SKELDTICPK
260
APKLEERLKV
270
LTNKASVMLF
280
MKGNKQEAKC
290
GFSRQILEIL
300
NSTGVDYETF
310
DILEDEEVRQ
320
GLKTYSNWPT
330
YPQLYVKGEL
340
VGGLDIVKEL
350
KENGELLPIL
KGEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.