Search Results
Overview
| Uniprot ID | A0A287BFB9 |
|---|---|
| Protein Name | Nuclear pore complex protein Nup50 |
| Gene Name | NUP50 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 333 | EEDAFYSKKCKLFYK |
| 348 | KDNEFKEKGVGTLHL |
| 362 | LKHTANQKTQLLVRA |
Function
Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B
Protein Sequence
10
MAKRIAEKEL
20
TDRNWDQEDE
30
AEESDSGGAF
40
KGFKGLVVPS
50
GGGGFSGFGN
60
SAGGKPLEGL
70
SNGSSVTAAP
80
PFSSSRAATE
90
AKTTFGSVAV
100
NGPASSVDKK
110
MSSPKTNGDS
120
QQPSASGLAS
130
STACPGNAYH
140
KQLAALNCSV
150
RDWIVKHVNT
160
NPLCDLTPIF
170
KDYEKYLASI
180
EQQHGNSGSS
190
HSESEKNKIA
200
VETQSPSLFG
210
SKLQQESTFL
220
FHGSTTEAAS
230
EKKMEALSEK
240
NKEPSLGAAS
250
ASFNFGKKID
260
SSVLGSLNSG
270
PLTGFSFSSG
280
NSSLFGKDTT
290
PSKPVSSPFS
300
AKTLETRAEG
310
GGNECRGGDE
320
EENDEPPKVV
330
VTEVKEEDAF
340
YSKKCKLFYK
350
KDNEFKEKGV
360
GTLHLKHTAN
370
QKTQLLVRAE
380
TNLGNILLNV
390
LIPPNMPCSR
400
TGKNNVLVLL
410
IPNPPIDATN
420
ASVPVTMLIR
430
VKTSEDADEL
440
HKILLEKKDS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0006606 | protein import into nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.