Search Results

Overview

Uniprot IDA0A287BFZ2
Protein NameProtein 4.1
Gene NameEPB41L2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
232 CDLEKRAKGQVLFDK
270 KNWVDPAKEIKRQLR
373 EKVAELYKTHRGLSP
451 KRSNFYIKVRPAELE
479 RAAKRLWKVCVEHHT
500 PEPPPKAKFLTLGSK
507 KFLTLGSKFRYSGRT
594 RDVRSLAKAPPVQYI
935 QRTEISTKEVPIVQT
989 THITKTVKGGISETR

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MTTEVGSASE 20 VKKESDQLGA 30 DATKEKPKEV 40 AENQQNQSSD 50 PEEEKGSQSS 60 PPAESQSSSR 70 PQKKERDPSG 80 SRGISRFIPP 90 WLKKQKSYTL 100 VVAKDGGDKK 110 EPTQAVVEEQ 120 ILAKEESLPE 130 EGKQAKGDAA 140 EMALQKQQQI 150 KVDVKEEKPP 160 VSSLEMQPVE 170 EVSKEREEEK 180 GKEIQEDTLD 190 EAAKRETKEV 200 QTNELKAEKA 210 SQKATKKTKT 220 VQCKVTLLDG 230 TEYSCDLEKR 240 AKGQVLFDKV 250 CEHLNLLEKD 260 YFGLVFQENP 270 EQKNWVDPAK 280 EIKRQLRNLP 290 WLFTFNVKFY 300 PPDPSQLTED 310 ITRYFLCLQL 320 RQDIASGRLP 330 CSLMTHALLG 340 SYTLQAELGD 350 YDPEEHDSND 360 LSDFQFAPTQ 370 TKELEEKVAE 380 LYKTHRGLSP 390 AQADSQFLEN 400 AKRLSMYGVD 410 LHHAKDSEGV 420 DIKLGVCANG 430 LLIYKDRLRI 440 NRFAWPKILK 450 ISYKRSNFYI 460 KVRPAELEQF 470 ESTIGFKLPN 480 HRAAKRLWKV 490 CVEHHTFYRL 500 VSPEPPPKAK 510 FLTLGSKFRY 520 SGRTQAQTRQ 530 ASTLIDRPAP 540 HFERTSSKRV 550 SRSLDGAPVG 560 VVDQSLMKDF 570 AGPAGEVSAY 580 GPGVVSPAVV 590 QDGDGRRDVR 600 SLAKAPPVQY 610 IEGKKNSLRV 620 EGDNIYVRHS 630 NLMLEDLDKA 640 QEEILKHQAS 650 ISELKRNFME 660 STPEPRPNEW 670 EKRRITPLSL 680 QTQGSKGDRL 690 FKDIFSMKEK 700 HQMAATRTVE 710 EKAQEADKKR 720 APESEGPCAG 730 ASDAVKSSHE 740 TLNVVEEKKQ 750 AEVGKDERVI 760 TEEVNGKALA 770 PGRGPGEMRK 780 VEPGTQKDST 790 SLSSESSPSS 800 ESEDEDVGEY 810 RPHHQVTEGT 820 IREEQEEEEE 830 VEEAPGPAAK 840 VVEREDPVPA 850 TRPVTHAGAN 860 VSTVETVIQE 870 NVVAPQIPTE 880 KSVNEGVKQD 890 VREDPEDEPQ 900 KVNGEVSHVD 910 IDVLPQVICC 920 SEPPVVKTEM 930 VTISDASQRT 940 EISTKEVPIV 950 QTETKTITYE 960 SPQIDGGAGG 970 DSGTLLTAQT 980 ITSESVSTTT 990 TTHITKTVKG 1000 GISETRIEKR 1010 IVITGDADID 1020 HDQALAQAIR 1030 EAREQHPDMS 1040 VTRVVVHKET ELEEGDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030054 cell junction
Cellular Component GO:0008180 COP9 signalosome
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0042731 PH domain binding
Molecular Function GO:0030507 spectrin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:1904778 positive regulation of protein localization to cell cortex

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.