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Overview

Uniprot ID	A0A287BG04
Protein Name	Protein phosphatase 1 regulatory subunit 12A
Gene Name	PPP1R12A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
197	INDVRHAKSGGTALH
209	ALHVAAAKGYTEVLK
320	SQKTFKNKETLIIEP
571	SSSYTRRKWEDDLKK
578	KWEDDLKKNSSINEG

Function

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity

Protein Sequence

10 MKMADAKQKR 20 NEQLKRWIGS 30 ETDLEPPVVK 40 RQKTKVKFDD 50 GAVFLAACSS 60 GDTDEVLKLL 70 HRGADINYAN 80 VDGLTALHQA 90 CIDDNVDMVK 100 FLVENGANIN 110 QPDNEGWIPL 120 HAAASCGYLD 130 IAEFLIGQGA 140 HVGAVNSEGD 150 TPLDIAEEEA 160 MEELLQNEVN 170 RQGVDIEAAR 180 KEEERIMLRD 190 ARQWLNSGHI 200 NDVRHAKSGG 210 TALHVAAAKG 220 YTEVLKLLIQ 230 AGYDVNIKDY 240 DGWTPLHAAA 250 HWGKEEACRI 260 LVDNLCDMEM 270 VNKVGQTAFD 280 VADEDILGYL 290 EELQKKQNLL 300 HSEKREKKSP 310 LIESTANMDN 320 NQSQKTFKNK 330 ETLIIEPEKN 340 ASRIESLEQE 350 KVDDEEEGKK 360 DESSCSSEED 370 EEDDSESEAE 380 TDKTKPMAPV 390 TNANTSSTQA 400 APVAVTTPTL 410 SSGQATPTSP 420 IKKYDFIAPI 430 MPVVESVDPA 440 SWRQGLRKTG 450 IVLVPSKGEK 460 SMFPTPATKI 470 SPKEEERKDE 480 SPASWRLGLR 490 KTGSYGALAE 500 ITASKEAQKE 510 KDTAGVIRSA 520 SSPRLSSSLD 530 NKEKEKDNKG 540 TRLAYVAPTI 550 PRRLASTSDM 560 EEKENRDSLG 570 LRTSSSYTRR 580 KWEDDLKKNS 590 SINEGSTYQK 600 SCSFGRRQDD 610 LISSSVPSTT 620 STPTVTSAAG 630 LQKGLLSSTS 640 TTTKITTGSS 650 SAGTQSRSYL 660 TPVRDEESES 670 QRKARSRQAR QSRRSHRYI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0001725	stress fiber
Molecular Function	GO:0019208	phosphatase regulator activity
Biological Process	GO:0007165	signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.