Search Results

Overview

Uniprot IDA0A287BGE8
Protein NameProgranulin
Gene NameGRN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
135 QHLGVPCKTKAQCPP
439 KGHTCVGKGHCKRKK
524 VKARTCEKEEDSALP

Function

Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8

Protein Sequence

10 MCSGQHLCSR 20 VYTRRKLNLR 30 PHTFLPAWMG 40 YSWGDSGSLG 50 AGAWGWGSDW 60 LQREGPSELK 70 LVAKSLLLFC 80 RWTMWTLVSW 90 VALVTGLVAG 100 TQCPDGQLCP 110 VACCLDPGGA 120 SYSCCNPVPD 130 KWPKALSQHL 140 GVPCKTKAQC 150 PPGHSCILTT 160 NETSNCCPFP 170 EAVSCRDGLH 180 CCPQGFHCSA 190 DGWSCLRRPD 200 TKPSDDILCP 210 NSQFHCPNSS 220 TCCTMLDGSW 230 GCCPMPQASC 240 CGDKVHCCPH 250 GTSCDLAHSR 260 CLTVTNTHPM 270 AKIPSQETIK 280 TGEEVGEVSS 290 GSWPGTSSPS 300 PWRPLTLFFS 310 FSRPVPRCAQ 320 CHQVSCPDDY 330 TCCRLQSGKW 340 GCCPFVQAVC 350 CNDHVHCCPT 360 GYQCNIEKGT 370 CDLETQWVPW 380 KEKIPASLSR 390 PDLLAMERDV 400 PCDNVSSCPS 410 SSTCCPVTPG 420 EWGCCPAPEA 430 VCCSDHQYCC 440 PKGHTCVGKG 450 HCKRKKDMVT 460 GLNKMPTRRA 470 SASQPGNTTG 480 CDQHTSCPVG 490 QTCCPSLSKG 500 WACCQLPHAV 510 CCEDRQHCCP 520 AGYTCNVKAR 530 TCEKEEDSAL 540 PATHLARVGD 550 VACGERRFCH 560 NNYTCCRDSL 570 GGWACCPYRQ 580 GICCADGRHC 590 CPAGFRCGAR 600 GTKCLHKEAL 610 RWDAPLRDPA PRQLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005764 lysosome
Molecular Function GO:0005125 cytokine activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.