Search Results
Overview
| Uniprot ID | A0A287BGK6 |
|---|---|
| Protein Name | Leucine-rich repeat protein SHOC-2 |
| Gene Name | LRRC40 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MSRLKGVAGRDP |
Function
Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c
Protein Sequence
10
MSRLKGVAGR
20
DPRAGFRNER
30
RDCAASVPQG
40
LLKAARKSGQ
50
LNLSGRNLSE
60
VPQCVWRINV
70
DIPEEANQNL
80
SFSATERWWE
90
QTDLTKLIIS
100
NNKLQSLSDD
110
LRLLPALTVL
120
DIHDNQLTSL
130
PSAIRELENL
140
QKLNVSHNKL
150
KILPEEITNL
160
RNLKGLYLQH
170
NELTCIPEGF
180
EQLFNLEDLD
190
LSNNRLSSIP
200
ASFSSLSSVV
210
RLNISSNQLK
220
SLPAEISGMK
230
RLKHLDCNSN
240
LLETIPPELA
250
SMESLELLYL
260
RRNKLRFLPE
270
FPSCKLLKEL
280
HVGENQIEML
290
GAEHLKHLNS
300
ILVLDLRDNK
310
LKSVPDEITL
320
LQSLERLDLS
330
NNDISSLPCS
340
LGKLHLKFLA
350
LEGNPLRTIR
360
REIINKGTQE
370
VLKYLRSKIK
380
DDGLSQSDCV
390
TETAMTLPSE
400
SRVNIHAIIT
410
LKTLDYSDKQ
420
TALIPDEVFD
430
AVKSNVITSV
440
NFSKNQLCEI
450
PKRIVEMKEM
460
VSDVNLSFNK
470
LSFISLELCM
480
LQKLTFLDLR
490
NNFLNSLPEE
500
MESLVRLQTI
510
NLSFNRFKIL
520
PEVLYRIPTL
530
ETILISNNQV
540
GSVDPQKMKT
550
MENLITLDLQ
560
NNDLLQIPPE
570
LGNCVNLRTL
580
LLDGNPFRVP
590
RAAILMKGTA
600
AILEYLRDRI
PS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0035556 | intracellular signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.