Search Results

Overview

Uniprot ID	A0A287BGM2
Protein Name	Protein 4.1
Gene Name	EPB41L3
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
269	RAAKRLWKVCVEHHT
289	LPEAPPKKFLTLGSK

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MQCKVILLDG 20 SEYTCDVEKR 30 SRGQVLFDKV 40 CEHLNLLEKD 50 YFGLTYRDAE 60 NQKNWLDPAK 70 EIKKQIRSGA 80 WHFSFNVKFY 90 PPDPAQLSED 100 ITRYYLCLQL 110 RDDIVSGRLP 120 CSFVTLALLG 130 SYTVQSELGD 140 YDPDECGSDY 150 VSEFRFAPNH 160 TKELEDKVIE 170 LHKSHRGMTP 180 AEAEMHFLEN 190 AKKLSMYGVD 200 LHHAKDSEGV 210 DIMLGVCASG 220 LLIYRDRLRI 230 NRFAWPKVLK 240 ISYKRNNFYI 250 KIRPGEFEQF 260 ESTIGFKLPN 270 HRAAKRLWKV 280 CVEHHTFFRL 290 LLPEAPPKKF 300 LTLGSKFRYS 310 GRTQAQTRRA 320 SALIDRPAPY 330 FERSSSKRYT 340 MSRSLDGASV 350 NENHEMYMKD 360 SVSAAEVGTG 370 QYATTKGISQ 380 TNLITTVTPE 390 KKAEEERDEE 400 EERRKKAEEA 410 TPVATVRHEG 420 KSPGLGTDSC 430 SLSPPSAHRA 440 PASPTELRRR 450 CKEKERPPPG 460 AEPSRDPGHL 470 CGEPTSDSDG 480 QGKPRLRDQD 490 VAFSYKQQAG 500 RGATLFSFSL 510 QLPASFPSLL 520 DDDGYLSFPS 530 LSETSLLPQS 540 LQHYLPIRSP 550 SLVPCFLFIF 560 FFLLSASFSV 570 PYALTLSFPL 580 ALCLCYLEPK 590 AASLSASLDN 600 DPSDSSEEET 610 DSERTDTAAD 620 GETTATEEML 630 HGDELDKTQD 640 DLMKHQTNIS 650 ELKRTFLETS 660 TDTAVTNEWE 670 KRLSTSPVRL 680 AARPEEAPMI 690 EPLVPEEKTE 700 TKTESSETET 710 ETTQRPQPLS 720 TETVVQETVL 730 VEERHVMSVH 740 ASGDASSTAG 750 DGVDAAAQAA 760 SAEASGVKGK 770 EGSALTEGAK 780 EDKGEVADRA 790 VLEQEVMATA 800 SQEPEEERLS 810 AAIHVSETLE 820 QKPHFESSTV 830 KTETISFGSV 840 SPGGIKLEIS 850 TKEVPVVHTE 860 TKTITYESSQ 870 VDLGADLEPG 880 VLMSAQTITS 890 ETTSTTTTTH 900 ITRTVKGGIS 910 ETRIEKRIVI 920 TGDADIDHDQ VVC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005856	cytoskeleton
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0030866	cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.