Search Results
Overview
| Uniprot ID | A0A287BGV0 |
|---|---|
| Protein Name | Sphingosine-1-phosphate lyase 1 |
| Gene Name | SGPL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 390 | SVVLYSDKKYRNYQF |
| 446 | EATKQIIKTTRFLKA |
| 452 | IKTTRFLKAELENIK |
Function
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance
Protein Sequence
10
MRGELGRRVG
20
GRHRKEGWKR
30
KMPSTDLLML
40
KAFEPYFEIL
50
EVYSTKAKNY
60
VNGHCTKYEP
70
WQLIAWSVVW
80
TLLIVWVYKF
90
VFQPESLWSR
100
FKKRCVKLIR
110
KMPVIGRKIQ
120
DKLNKTKDDI
130
SKNMSFLKVD
140
KEYVKALPSQ
150
GLSPAAVLEK
160
LKEYSSLDVS
170
WQEGKASGAV
180
YSGEKELTEL
190
LVKAYGDFAW
200
SNPLHPDIFP
210
GLRKIEAEIV
220
RMACSLFNGG
230
PDSCGCVTSG
240
GTESILMACK
250
AYRELAFENG
260
IKTPEIVAPQ
270
SAHAAFDKAA
280
NYFGMKIIRV
290
PLNKMMEVDI
300
RAMRRAISRN
310
TAMLVCSTPQ
320
YPHGVIDPVP
330
EVAKLAVKYK
340
IPLHVDACLG
350
GFLIVFMEKA
360
GYPLEQPFDF
370
RVKGVTSISA
380
DTHKYGYAPK
390
GSSVVLYSDK
400
KYRNYQFFVA
410
TDWQGGIYAS
420
PTMAGSRPGG
430
ISAACWAALM
440
YFGENGYVEA
450
TKQIIKTTRF
460
LKAELENIKG
470
IFVFGNPQLS
480
VIALGSRDFD
490
IFRLFNLMTA
500
KGWNLNQLQF
510
PPSIHFCITL
520
VHTRKRVAIQ
530
FLKDIRESVT
540
QIMKNPKAKT
550
TGMGAIYGMA
560
QATIDRNLVA
570
ELSSFFLDSL
580
FSTDAVPQGS
QMNGSPKPR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0008117 | sphinganine-1-phosphate aldolase activity |
| Biological Process | GO:0019752 | carboxylic acid metabolic process |
| Biological Process | GO:0006665 | sphingolipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.