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Overview

Uniprot IDA0A287BGW5
Protein NameArmadillo repeat-containing X-linked protein 3
Gene NameARMCX3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
180 NTRDPIVKEKALIVL

Function

Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters

Protein Sequence

10 MGYARKVGWV 20 TAGLVIGAGA 30 CYCIYRLTRG 40 RKQNKEKMAE 50 GGSGDVDDVG 60 DCPGARYNDW 70 SDDDDDNSEN 80 KGIVWYPPWA 90 RIGTEAGTRA 100 RARARARATR 110 ARRAVQKRAS 120 PNSDDTVLSP 130 QELQKVLCLV 140 EMSEKPYILE 150 AALIALGNNA 160 AYAFNRDIIR 170 DLGGLPIVAK 180 ILNTRDPIVK 190 EKALIVLNNL 200 SVNAENQRRL 210 KIYMNQVCDD 220 TITSRLNSSV 230 QLAGLRLLTN 240 MTVTNEYQHM 250 LANSISDFFR 260 LFSAGNEETK 270 FQVLKLLLNL 280 AENPAMTREL 290 LRAQVPSSLG 300 SLFNKKENKE 310 VILKLLVIFE 320 NIIDNFKWEE 330 DEPTQNQFSE 340 GSLFFFLKEF 350 QVCADKILGI 360 ESHQDFLVKV 370 KVGKFMAKLA EHMFPKSQE

Gene Ontology

Classification GO ID Description
Cellular Component GO:1904115 axon cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Biological Process GO:0019896 axonal transport of mitochondrion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.