Overview
| Uniprot ID | A0A287BHA3 |
|---|
| Protein Name | Regulator of chromosome condensation |
|---|
| Gene Name | RCC1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 316 |
TSFKNSTKSWVRFSG |
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA
Protein Sequence
10
MPPKRIAKRR
20
SPPEDALPKS
30
KKVKDPCNQA
40
VRAVASRRVP
50
GARSCQVSHR
60
SHSTEPGLVL
70
TLGQGDVGQL
80
GLGENVMERK
90
KPALVPIPED
100
IVQAEAGGMH
110
TVCLSKSGQV
120
YSFGCNDEGA
130
LGRDTSVEGS
140
EMVPGKVELQ
150
EKVVQVSAGD
160
SHTAALTEDG
170
RVFLWGSFRD
180
NNGVIGLLEP
190
MKKSMVPVQV
200
QLSMPVVKVA
210
SGNDHLVMLT
220
ADGELYTLGS
230
GEQGQLGRVP
240
ELFANRGGRQ
250
GLERLLVPKC
260
VMLKSRGSRG
270
HVRFQDAFCG
280
AYFTFAISSE
290
GHVYGFGLSN
300
YHQLGTPGTE
310
SCFVPQNLTS
320
FKNSTKSWVR
330
FSGGQHHTVC
340
MDSEGRAYSL
350
GRAEYGRLGL
360
GEGAEEKSVP
370
TLISRLPAVS
380
SVACGASVGY
390
AVTKDGRVFA
400
WGMGTNYQLG
410
TGQEEDAWSP
420
VEMTGKQLEN
430
RMVLSVSSGG
440
QHTVLLVKDK
EQS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0000794 |
condensed nuclear chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0031492 |
nucleosomal DNA binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Molecular Function |
GO:0043199 |
sulfate binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0000082 |
G1/S transition of mitotic cell cycle |
| Biological Process |
GO:0007052 |
mitotic spindle organization |
| Biological Process |
GO:0090068 |
positive regulation of cell cycle process |
| Biological Process |
GO:0007346 |
regulation of mitotic cell cycle |
| Biological Process |
GO:0007088 |
regulation of mitotic nuclear division |
| Biological Process |
GO:1901673 |
regulation of mitotic spindle assembly |
| Biological Process |
GO:0051225 |
spindle assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.