Search Results
Overview
| Uniprot ID | A0A287BHR9 |
|---|---|
| Protein Name | Transmembrane protein 59 |
| Gene Name | TMEM59 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | YPLHTYPKEEELYAC |
Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding
Protein Sequence
10
MAAPKGSLWV
20
RAQLGLLPLL
30
LLTMALAGGP
40
GTASAEAFDS
50
VLGDTASCHR
60
ACQLTYPLHT
70
YPKEEELYAC
80
QRGCRLFSIC
90
QFVDDGIDLN
100
RTKLECESAC
110
TEAYSQSDEQ
120
YACHLGCQNQ
130
LPFAELRQEQ
140
LMSLMPKMHL
150
LFPLTLVRSF
160
WSDVMDSAQS
170
FITSSWTFYL
180
QADDGKIVIF
190
QSKPEIQYAP
200
QLEQEPTNLK
210
ESSLSKMSYL
220
QMRSSQAHRN
230
YLEDGENDGF
240
LRCLSLNSGW
250
ILTMTLVLSV
260
MVLLWICCAT
270
VATAVEQYVP
280
SEDAPCTRKM
290
SKKLVWLLPG
300
RLTCWPQVEF
310
TLLNSPPPKF
320
WFPGLPTNVE
330
HFLLVTVQHV
340
LHELAHLVLL
LTL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000137 | Golgi cis cisterna |
| Cellular Component | GO:0005797 | Golgi medial cisterna |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0000138 | Golgi trans cisterna |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004175 | endopeptidase activity |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:1903077 | negative regulation of protein localization to plasma membrane |
| Biological Process | GO:0010508 | positive regulation of autophagy |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.