Search Results

Overview

Uniprot IDA0A287BHV8
Protein NamePre-mRNA-processing factor 40 homolog A
Gene NamePRPF40A
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
225 LLSKCPWKEYKSDSG

Function

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing

Protein Sequence

10 MQATPSEAEV 20 GSESPKSCVS 30 AAQSDWTAEK 40 PVSLLAPLVP 50 PRSAGQPLTF 60 GPSGLQPLRS 70 LLVGMCSGSG 80 RRRSSLSPTM 90 RPGTGAERGG 100 LMMGHPSMHY 110 APMGMHPMGQ 120 RANMPPVPHG 130 MMPQMMPPMG 140 GPPMGQMPGM 150 MSSVMPGMMM 160 SHMSQASMQP 170 ALPPGVNNMD 180 VAAGATSGAK 190 SMWTEHKSPD 200 GRTYYYNTET 210 KQSTWEKPDD 220 LKTPAEQLLS 230 KCPWKEYKSD 240 SGKPYYYNSQ 250 TKESRWAKPK 260 ELEDLEGYQN 270 TIVAGSLITK 280 SNLHAMIKAE 290 ESSKQEECTT 300 TSAAPVPTTE 310 IPTTMSTMAA 320 AEAAAAVVAA 330 AAAAAAAAAA 340 ANASASTSAS 350 STVGGTVPVV 360 PEPEVTSIVA 370 TVVDNENTVT 380 ISTEEQAQLT 390 STPAVQDQSV 400 EVSSNTGEET 410 SKQEAVADFT 420 PKKEEEENQP 430 AKKTYTWNTK 440 EEAKQAFKEL 450 LKEKRVPSNA 460 SWEQAMKMII 470 NDPRYSALAK 480 LSEKKQAFNA 490 YKVQTEKEEK 500 EEARSKYKEA 510 KESFQRFLEN 520 HEKMTSTTRY 530 KKAEQMFGEM 540 EVWNAISERD 550 RLEIYEDVLF 560 FLSKKEKEQA 570 KQLRKRNWEA 580 LKNILDNMAN 590 VTYSTTWSEA 600 QQYLMDNPTF 610 AEDEELQNMD 620 KEDALICFEE 630 HIRALEKEEE 640 EEKQKSLLRE 650 RRRQRKNRES 660 FQIFLDELHE 670 HGQLHSMSSW 680 MELYPTISSD 690 IRFTNMLGQP 700 GSTALDLFKF 710 YVEDLKARYH 720 DEKKIIKDIL 730 KDKGFVVEVN 740 TTFEDFVAII 750 SSTKRSTTLD 760 AGNIKLAFNS 770 LLEKAEARER 780 EREKEEARKM 790 KRKESAFKSM 800 LKQATPPIEL 810 DAVWEDIRER 820 FVKEPAFEDI 830 TLESERKRIF 840 KDFMHVLEHE 850 CQHHHSKNKK 860 HSKKSKKHHR 870 KRSRSRSGSD 880 SDDDDSHSKK 890 KRQRSESRSA 900 SEHSSSAESE 910 RSYKKSKKHK 920 KKSKKRRHKS 930 DSPESDAERE 940 KDKKEKDRES 950 EKDRTRQRSE 960 SKHKSPKKKT 970 GKDSGNWDTS 980 GSELSEGELE 990 KRRRTLLEQL DDDQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005685 U1 snRNP
Cellular Component GO:0071004 U2-type prespliceosome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0045292 mRNA cis splicing, via spliceosome
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.