Overview
| Uniprot ID | A0A287BI04 |
|---|
| Protein Name | Annexin |
|---|
| Gene Name | ANXA2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 225 |
KVQCIQNKPLYFADR |
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis
Protein Sequence
10
MFVFSPQHST
20
PASAYGSVKA
30
YTNFDAERDA
40
LNIETAIKTK
50
GVDEVTIVNI
60
LTNRSNEQRQ
70
DIAFAYQRRT
80
KKELASALKS
90
ALSGHLETVI
100
LGLLKTPAQY
110
DASELKASMK
120
GLGTDEDSLI
130
EIICSRTNQE
140
LQEINRVYKE
150
MYKTDLEKDI
160
ISDTSGDFRK
170
LMVALAKGRR
180
AEDGSVIDYE
190
LIDQDARDLY
200
DAGVKRKGTD
210
VPKWISIMTE
220
RSVCHLQKVQ
230
CIQNKPLYFA
240
DRLYDSMKGK
250
GTRDKVLIRI
260
MVSRSEVDML
270
KIRSEFKRKY
280
GKSLYNYIQQ
290
DTKGDYQKAL
LYLCGGDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005604 |
basement membrane |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005544 |
calcium-dependent phospholipid binding |
| Molecular Function |
GO:0008092 |
cytoskeletal protein binding |
| Molecular Function |
GO:0004859 |
phospholipase inhibitor activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.