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Overview

Uniprot IDA0A287BIL4
Protein NameProtein 4.1
Gene NameEPB41L2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
232 CDLEKRAKGQVLFDK
270 KNWVDPAKEIKRQLR
373 EKVAELYKTHRGLSP
451 KRSNFYIKVRPAELE
479 RAAKRLWKVCVEHHT
500 PEPPPKAKFLTLGSK
507 KFLTLGSKFRYSGRT
594 RDVRSLAKAPPVQYI
865 QRTEISTKEVPIVQT
919 THITKTVKGGISETR

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MTTEVGSASE 20 VKKESDQLGA 30 DATKEKPKEV 40 AENQQNQSSD 50 PEEEKGSQSS 60 PPAESQSSSR 70 PQKKERDPSG 80 SRGISRFIPP 90 WLKKQKSYTL 100 VVAKDGGDKK 110 EPTQAVVEEQ 120 ILAKEESLPE 130 EGKQAKGDAA 140 EMALQKQQQI 150 KVDVKEEKPP 160 VSSLEMQPVE 170 EVSKEREEEK 180 GKEIQEDTLD 190 EAAKRETKEV 200 QTNELKAEKA 210 SQKATKKTKT 220 VQCKVTLLDG 230 TEYSCDLEKR 240 AKGQVLFDKV 250 CEHLNLLEKD 260 YFGLVFQENP 270 EQKNWVDPAK 280 EIKRQLRNLP 290 WLFTFNVKFY 300 PPDPSQLTED 310 ITRYFLCLQL 320 RQDIASGRLP 330 CSLMTHALLG 340 SYTLQAELGD 350 YDPEEHDSND 360 LSDFQFAPTQ 370 TKELEEKVAE 380 LYKTHRGLSP 390 AQADSQFLEN 400 AKRLSMYGVD 410 LHHAKDSEGV 420 DIKLGVCANG 430 LLIYKDRLRI 440 NRFAWPKILK 450 ISYKRSNFYI 460 KVRPAELEQF 470 ESTIGFKLPN 480 HRAAKRLWKV 490 CVEHHTFYRL 500 VSPEPPPKAK 510 FLTLGSKFRY 520 SGRTQAQTRQ 530 ASTLIDRPAP 540 HFERTSSKRV 550 SRSLDGAPVG 560 VVDQSLMKDF 570 AGPAGEVSAY 580 GPGVVSPAVV 590 QDGDGRRDVR 600 SLAKAPPVQY 610 IEGKSKGDRL 620 FKDIFSMKEK 630 HQMAATRTVE 640 EKAQEADKKR 650 APESEGPCAG 660 ASDAVKSSHE 670 TLNVVEEKKQ 680 AEVGKDERVI 690 TEEVNGKALA 700 PGRGPGEMRK 710 VEPGTQKDST 720 SLSSESSPSS 730 ESEDEDVGEY 740 RPHHQVTEGT 750 IREEQEEEEE 760 VEEAPGPAAK 770 VVEREDPVPA 780 TRPVTHAGAN 790 VSTVETVIQE 800 NVVAPQIPTE 810 KSVNEGVKQD 820 VREDPEDEPQ 830 KVNGEVSHVD 840 IDVLPQVICC 850 SEPPVVKTEM 860 VTISDASQRT 870 EISTKEVPIV 880 QTETKTITYE 890 SPQIDGGAGG 900 DSGTLLTAQT 910 ITSESVSTTT 920 TTHITKTVKG 930 GISETRIEKR 940 IVITGDADID 950 HDQALAQAIR 960 EAREQHPDMS 970 VTRVVVHKET ELEEGDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.