Search Results

Overview

Uniprot IDA0A287BJC6
Protein NameGelsolin
Gene NameGSN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
143 GGVASGFKHVVPNEV
159 VQRLFQVKGRRVVRA
211 LKATQVSKGIRDNER
304 CFILDHGKDGKIFVW
307 LDHGKDGKIFVWKGK
312 DGKIFVWKGKQANTE
326 EERKAALKTASDFIS
641 RLFACSNKIGRFVIE
694 TEALTSAKRYIETDP

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis

Protein Sequence

10 MAEEEALGGD 20 SDPWPSTMVV 30 EHPEFLKAGK 40 EPGLQIWRVE 50 KFDLVPVPPN 60 LYGDFFTGDA 70 YVILKTVQLR 80 NGNLQYDLHY 90 WLGNECSQDE 100 SGAAAIFTVQ 110 LDDYLNGRAV 120 QHREVQGFES 130 ATFLGYFKSG 140 LKYKKGGVAS 150 GFKHVVPNEV 160 AVQRLFQVKG 170 RRVVRATEVP 180 VSWESFNRGD 190 CFILDLGNDI 200 YQWCGSNSNR 210 YERLKATQVS 220 KGIRDNERSG 230 RAHVHVSEED 240 AEPAGMLQVL 250 GPKPTLPEGT 260 EDTVKEDAAN 270 RKLAKLYKVS 280 NGAGTMTVSL 290 VADENPFAQG 300 ALKSEDCFIL 310 DHGKDGKIFV 320 WKGKQANTEE 330 RKAALKTASD 340 FISKMNYPKQ 350 TQVSVLPEGG 360 ETPLFKQFFK 370 NWRDPDQVDG 380 PGLSYLSSHI 390 ANVERVPFDA 400 ATLHTSTAMA 410 AQHGMDDDGT 420 GQKQIWRIEG 430 SNKVPVDPAT 440 YGQFYGGDSY 450 IILYNYRHGG 460 RQGQIIYNWQ 470 GAQSTQDEVA 480 ASAILTAQLD 490 EELGGTPVQS 500 RVVQGKEPAH 510 LMSLFGGKPM 520 IIYRGGTSRE 530 GGQTAPASTR 540 LFQVRASSSG 550 ATRAVEVIPK 560 AGALNSNDAF 570 VLKTPSAAYL 580 WVGTGASEAE 590 KTGAQELLRV 600 LRAQPVQVAE 610 GSEPDSFWEA 620 LGGKAAYRTS 630 PRLKDKKMDA 640 HPPRLFACSN 650 KIGRFVIEEV 660 PGELMQEDLA 670 TDDVMLLDTW 680 DQVFVWVGKD 690 SQEEEKTEAL 700 TSAKRYIETD 710 PANRDRRTPI 720 NVVKQGFEPP 730 SFVGWFLSWD 740 DNYWSVDPLD RAIAELAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0051014 actin filament severing
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0060271 cilium assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.